Oxidative Stress, Antioxidant Status and Inflammation in Chronic Bronchitis and Pulmonary Emphysema

• Main Authors: Cristina Cristóvão (Author), Luísa Cristóvão (Author), Fernando Nogueira (Author), Manuel Bicho (Author)
• Format: Book
• Published: Archives of Pulmonology and Respiratory Care - Peertechz Publications, 2017-03-06.
• Subjects: Research Article
• Online Access: Connect to this object online.

Summary

<p><strong>Background:</strong> Chronic Obstructive Pulmonary Disease (COPD) is characterized by a complex range of pathological changes including both pulmonary and systemic effects. Several mechanisms contribute to  the variable intermediate and clinically relevant disease phenotypes, such as chronic bronchitis and emphysema, and systemic disease. The molecular mechanisms associated to the pathogenesis of COPD are not yet clearly understood. </p><p><strong>Objective:</strong> The aim of  this study was to evaluate oxidant/antioxidant balance and the systemic  inflammation in chronic bronchitis and pulmonary emphysema COPD patients. </p><p><strong>Methods:</strong> We analyzed COPD patients divided in 2 groups: chronic bronchitis and emphysema. Healthy volunteers without lung disease were used as control group. </p><p><strong>Results:</strong> We observed a significant (P<0,05) increase in the levels of plasma malondialdehyde (MDA), a marker of oxidative stress, an increase in the circulating C-reactive protein (CRP), used as a biomarker of systemic inflammation, and a decrease in antioxidant defense in COPD patients with emphysema when compared with COPD patients with chronic bronchitis. </p><p><strong>Conclusion:</strong> Althought our results should be regarded as preliminary they indicate a disturbance in  oxidant/antioxidant status and systemic inflammatory response associated to COPD patients. The  differences observed were more evident in emphysematous phenotype.</p>

DOI

10.17352/aprc.000015