Metal and organic characterization of bladder stones removed surgically from VesicoVaginal Fistula patients at the National Obstetric Fistula Centre, Abakaliki, Ebonyi State

<p>Objectives: Complication of obstetric fistula is the formation of bladder stones which rarely occur in Vagina-Vesico Fistula (VVF) patients. In this study, the metal and organic characterization of bladder stones removed between 2010-2019 from vesicovaginal fistula patients managed at the N...

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Hoofdauteurs: Okorie UC (Auteur), Sunday-Adeoye I (Auteur), Obuna JA (Auteur), Daniyan ABC (Auteur), Ekwedigwe KC (Auteur), Oje AO (Auteur), Yakubu EN (Auteur), Chukwu CJ (Auteur), Uro-Chukwu (Auteur), Omaka ON (Auteur)
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Gepubliceerd in: Archive of Urological Research - Peertechz Publications, 2022-05-11.
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LEADER 00000 am a22000003u 4500
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042 |a dc 
100 1 0 |a Okorie UC  |e author 
700 1 0 |a  Sunday-Adeoye I  |e author 
700 1 0 |a  Obuna JA  |e author 
700 1 0 |a  Daniyan ABC  |e author 
700 1 0 |a  Ekwedigwe KC  |e author 
700 1 0 |a  Oje AO  |e author 
700 1 0 |a  Yakubu EN  |e author 
700 1 0 |a  Chukwu CJ  |e author 
700 1 0 |a  Uro-Chukwu  |e author 
700 1 0 |a Omaka ON  |e author 
245 0 0 |a Metal and organic characterization of bladder stones removed surgically from VesicoVaginal Fistula patients at the National Obstetric Fistula Centre, Abakaliki, Ebonyi State 
260 |b Archive of Urological Research - Peertechz Publications,   |c 2022-05-11. 
520 |a <p>Objectives: Complication of obstetric fistula is the formation of bladder stones which rarely occur in Vagina-Vesico Fistula (VVF) patients. In this study, the metal and organic characterization of bladder stones removed between 2010-2019 from vesicovaginal fistula patients managed at the National Obstetric Fistula Centre (NOFIC), Abakaliki, Ebonyi State, Nigeria were carried out. </p><p>Methods: The solubility of the bladder stones in different solvents were investigated and metal compositions were determined using Inductively Coupled Plasma- Optical Emission Spectrometry (ICP-OESS). The qualitative chemical composition was determined following standard procedures while the structural chemical characterization and functional groups were determined using the Gas Chromatography-Mass Spectrometry (GC-MS) and Fourier-Transform Infrared spectroscopy (FTIR). </p><p>Results: Distilled water and aqueous solvent chloroform extract of W. lateritia demonstrated significant capacity to dissolve bladder stones in-vitro. Chemical compounds identified include uric acid, oxalate, cysteine, and phosphate from the bladder stones. The metals found in the bladder stones were: Ca, Na, Cu, Zn, Mg, B, Pb, and Al. Trace elements can influence the external morphology of growing crystals and may increase or decrease the speed of the crystallization process. The GC-MS revealed the presence of the following compounds: methyl 2-Hydroxyethyl sulfoxide; methylene chloride; mercaptamine;1,1diethoxy, dichloroactealdehyde; Cyclopentasiloxane; monoammonium salt; di-Allo-Cystathionine; dichloroacetaldehyde; 2-(2Furyl)-2,5-dimethyltetrahydrofuran; Methenamine; 1,1-Difluoro-1-sila-5-thiacyclooctane; Triacetonetriperoxde; 4-Aminosalicylic acid, 3-Trimethylsilyl (3TMS) derivative;Pentanethiol; and 2,5-Bis-(5-hexyl-[1,3,2]dioxaborinan-2-yloxy)-benzene. FTIR revealed the following: hydroxyl, carboxylic, ester, aromatic, and aliphatic groups, confirming the compounds identified. </p><p>Conclusion: Metals (Mg, Ca, Pb, etc), organic metabolites (oxalate, cystine, uric acid, phosphate, methenamine, methylene chloride, 4-Aminosalicylic acid, 3-Trimethylsilyl, etc) were found in the bladder stones. </p> 
540 |a Copyright © Okorie UC et al. 
546 |a en 
655 7 |a Research Article  |2 local 
856 4 1 |u https://doi.org/10.17352/aur.000037  |z Connect to this object online.