Genetic Polymorphisms and Cisplatin- Related Nephrotoxicity
<p>Cis- diamminedichloroplatinum (cisplatin) is one of the most commonly used present day hemotherapeutic agents. It is used to treat a wide range of cancers including head and neck, lung, gastrointestinal tract, ovarian and genitourinary cancers. However, dose- limiting toxicity is often asso...
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Global Journal of Cancer Therapy - Peertechz Publications,
2015-01-07.
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LEADER | 00000 am a22000003u 4500 | ||
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001 | peertech__10_17352_gjct_000001 | ||
042 | |a dc | ||
100 | 1 | 0 | |a Arundhati Bag |e author |
700 | 1 | 0 | |a Lalit Mohan Jeena |e author |
700 | 1 | 0 | |a Niladri Bag |e author |
245 | 0 | 0 | |a Genetic Polymorphisms and Cisplatin- Related Nephrotoxicity |
260 | |b Global Journal of Cancer Therapy - Peertechz Publications, |c 2015-01-07. | ||
520 | |a <p>Cis- diamminedichloroplatinum (cisplatin) is one of the most commonly used present day hemotherapeutic agents. It is used to treat a wide range of cancers including head and neck, lung, gastrointestinal tract, ovarian and genitourinary cancers. However, dose- limiting toxicity is often associated with cisplatin. It is known that cisplatin works more effectively with dose escalation, but significant risk for nephrotoxicity is often associated with higher doses [1]. <br></p><p>Recovery of renal function occurs over a period of 2-4 weeks, although lack of recovery can also take place [2]. Kidney accumulates cisplatin in much higher concentration in comparison to other organs and is the major route of its excretion [3]. Five times higher cisplatin concentration was observed in proximal tubular epithelial cells in comparison to serum [4]. Highest accumulation of cisplatin occurs in S3 segment of proximal tubule followed by the distal collecting tubule and the S1 segment of proximal tubule [5]. Cisplatin nephrotoxicity may be presented in various ways of which the most serious presentation is acute kidney injury, which occurs in 20-30% of patients despite hyperhydration and forced Diuresis [6].</p> | ||
540 | |a Copyright © Arundhati Bag et al. | ||
546 | |a en | ||
655 | 7 | |a Review Article |2 local | |
856 | 4 | 1 | |u https://doi.org/10.17352/gjct.000001 |z Connect to this object online. |