Altered endometrial receptivity causes failure of IVF/ICSI in cases with tubal factor infertility

• Main Authors: Gunjan Sabherwal (Author), Sonia Malik (Author)
• Format: Book
• Published: Global Journal of Fertility and Research - Peertechz Publications, 2018-09-12.
• Subjects: Research Article
• Online Access: Connect to this object online.

<p>Objectives: To study the prevalence of non- receptive endometrium in patients with tubal factor infertility and to compare that with patients with infertility due to other causes. Further, to analyse the association between endometrial non-receptivity in patients with tubal factor infertility (cases), and their previous history of diagnosis and treatment of genital tuberculosis. </p><p>Materials and Methods: We carried out an analytical cross sectional study with 63 patients of recurrent implantation failure, who took ERA test in a period between 01.05.15 to 30.04.17.</p><p>For patients aged 40 years or less, own egg IVF and for those aged 40 years ovum donor IVF was carried out. </p><p>All patients had HRT cycles. Endometrial Biopsy was taken when endometrial thickness was 7.5mm or more, after proper oestrogen priming and after 5 days of progesterone vaginal pessaries i.e. at P+5 days.</p><p>The sample was tested for ERA transcriptomic analyses </p><p>Observations were tabulated and analysed.</p><p>Patients in whom ERA result showed non- receptive report, were advised to undergo a repeat ERA test to exactly find the receptivity status. Most of the patients denied the repeat test due to time and financial constraints.</p><p>Conclusion: Tubal damage unilaterally or bilaterally has an impact on endometrial receptivity either due to damage causing causative agent or some unknown (yet to be discovered) chemical released from the fallopian tubes that acts on the endometrium at molecular level. This may be a reason for repeated implantation failures. Thus it is important to consider the cause of tubal damage and treat it before attempting ART.</p>