Familial Goiter and Related Disorders
<p>Synthesis, storage, secretion, delivery, and utilization of thyroid hormones are dependent upon specific enzymatic activity; inherited disorders may cause thyroid disease. Studies of a cretinous patient from consanguine marriage have indicated a limited response to thyrotrophic (TSH), both...
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Main Authors: | , , , , |
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Format: | Book |
Published: |
International Journal of Clinical Endocrinology and Metabolism - Peertechz Publications,
2015-11-20.
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Online Access: | Connect to this object online. |
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Summary: | <p>Synthesis, storage, secretion, delivery, and utilization of thyroid hormones are dependent upon specific enzymatic activity; inherited disorders may cause thyroid disease. Studies of a cretinous patient from consanguine marriage have indicated a limited response to thyrotrophic (TSH), both in synthesis of the specific thyroid protein thyroglobulin and in cell growth and division. Other similar response has been observed in a strain of mice. Familial goiter and hypothyroidism may occur when there is failure of the thyroid cell to transport iodide.</p> |
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DOI: | 10.17352/ijcem.000010 |