A Pharmacokinetic Analysis and Pharmacogenomic Study of 6-mercaptopurine
<p><strong>Background:</strong> The efficacy and safety of 6-mercaptopurine (6-MP) therapy rely on the concentration of its metabolites. The aim of the current study is the pharmacokinetic analysis of 6-MP and the detection of its metabolites as well as the role of Thiopurine S-met...
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| Main Authors: | , , , , , , , , , , |
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International Journal of Pharmaceutical Sciences and Developmental Research - Peertechz Publications,
2015-05-23.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | peertech__10_17352_ijpsdr_000002 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Vicha A |e author |
| 700 | 1 | 0 | |a Katsila T |e author |
| 700 | 1 | 0 | |a Giannopoulou E |e author |
| 700 | 1 | 0 | |a Leontari H |e author |
| 700 | 1 | 0 | |a El Mubarak M |e author |
| 700 | 1 | 0 | |a Gravia A |e author |
| 700 | 1 | 0 | |a Chondrou V |e author |
| 700 | 1 | 0 | |a Symeonidis A |e author |
| 700 | 1 | 0 | |a Patrinos GP |e author |
| 700 | 1 | 0 | |a Kalofonos HP |e author |
| 700 | 1 | 0 | |a Sivolapenko G |e author |
| 245 | 0 | 0 | |a A Pharmacokinetic Analysis and Pharmacogenomic Study of 6-mercaptopurine |
| 260 | |b International Journal of Pharmaceutical Sciences and Developmental Research - Peertechz Publications, |c 2015-05-23. | ||
| 520 | |a <p><strong>Background:</strong> The efficacy and safety of 6-mercaptopurine (6-MP) therapy rely on the concentration of its metabolites. The aim of the current study is the pharmacokinetic analysis of 6-MP and the detection of its metabolites as well as the role of Thiopurine S-methyl transferase (TPMT), the enzyme associated with 6-MP metabolism, as a pharmacogenomics biomarker.</p><p><strong>Materials and Methods:</strong> Data were collected from 19 patients with different types of leukemia and lymphoma who received 6-MP chemotherapy. Pharmacokinetic analysis was performed using an HPLC. The VNTR promoter polymorphisms of TPMT were detected.</p><p><strong>Results and Conclusion:</strong> The pharmacokinetic analysis confirmed the heterogeneity of the 6-MP metabolism. The TPMT genotyping revealed a correlation between the TPMT*3C variant and increased levels of 6-thioguanine nucleotides (TGs). No methylation pattern was obtained.</p> | ||
| 540 | |a Copyright © Vicha A et al. | ||
| 546 | |a en | ||
| 655 | 7 | |a Research Article |2 local | |
| 856 | 4 | 1 | |u https://doi.org/10.17352/ijpsdr.000002 |z Connect to this object online. |