In-silico analysis of tenidap and its derivative as a novel 5-lipoxygenase inhibitor
<p>Tenidap is a derivative of Flavonoids which are actually plant derivatives, it shows inhibition activity</p><p>of 5-lipoxygenase. Molecular models were directed to discover molecular docking mode, also to help</p><p>explain molecular tool behind its inhibitory action...
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| Main Authors: | , , , , |
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| Format: | Book |
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International Journal of Pharmaceutical Sciences and Developmental Research - Peertechz Publications,
2017-11-24.
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| Online Access: | Connect to this object online. |
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| Summary: | <p>Tenidap is a derivative of Flavonoids which are actually plant derivatives, it shows inhibition activity</p><p>of 5-lipoxygenase. Molecular models were directed to discover molecular docking mode, also to help</p><p>explain molecular tool behind its inhibitory action. Molecular relations of tenidap with the catalytic trio</p><p>(His523, His518, Ile875) inside active or dynamic position of 5-lipoxygenase through hydrogen bonding,</p><p>appears to the major reason elaborate in its substantial 5-lipoxygenase activity of inhibition.</p> |
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| DOI: | 10.17352/ijpsdr.000015 |