Chronic (52-week) oral toxicity study of herbal tea of Moringa stenopetala and Mentha spicata leaves formulation in Wistar albino rats

<p>Background: Moringa stenopetala leaves have long been used to treat diabetes, hypertension, respiratory problems, and other diseases. The herbal formulation of Moringa stenopetala and Mentha spicata leaves was found to be more effective in lowering high blood pressure and blood sugar levels...

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Main Authors: Abdu Hassen Musa (Author), Girmai Gebru (Author), Asfaw Debella (Author), Eyasu Makonnen (Author), Mesfin Asefa (Author), Samuel Woldekidan (Author), Boki Lengiso (Author), Chala Bashea (Author)
Format: Book
Published: International Journal of Pharmaceutical Sciences and Developmental Research - Peertechz Publications, 2022-05-25.
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001 peertech__10_17352_ijpsdr_000038
042 |a dc 
100 1 0 |a Abdu Hassen Musa  |e author 
700 1 0 |a  Girmai Gebru  |e author 
700 1 0 |a  Asfaw Debella  |e author 
700 1 0 |a  Eyasu Makonnen  |e author 
700 1 0 |a  Mesfin Asefa  |e author 
700 1 0 |a  Samuel Woldekidan  |e author 
700 1 0 |a  Boki Lengiso  |e author 
700 1 0 |a Chala Bashea  |e author 
245 0 0 |a Chronic (52-week) oral toxicity study of herbal tea of Moringa stenopetala and Mentha spicata leaves formulation in Wistar albino rats 
260 |b International Journal of Pharmaceutical Sciences and Developmental Research - Peertechz Publications,   |c 2022-05-25. 
520 |a <p>Background: Moringa stenopetala leaves have long been used to treat diabetes, hypertension, respiratory problems, and other diseases. The herbal formulation of Moringa stenopetala and Mentha spicata leaves was found to be more effective in lowering high blood pressure and blood sugar levels. Unlike its pharmacological properties, the long-term safety profile of this herbal formulation has not been investigated yet. Thus, this study investigated the long-term (chronic) oral toxicity of herbal tea of M. stenopetala and M. spicata leaves blended in rats. </p><p>Methods: Wistar albino rats were randomly distributed into four groups (n = 10/sex/group), and then randomly assigned to a control group and three test groups. The control group (G I) received distilled water. The test groups (G II-IV) received 559.36, 1118.72, and 2237.44 mg/kg of herbal tea of M. stenopetala and M. spicata leaves blend respectively, for 360 consecutive days. During the treatment period, in-life parameters (mortality, clinical symptoms, body weight, and food intake) were evaluated. On the 361st day, hematological, serum biochemical, gross morphological, and histological parameters were investigated.</p><p>Results: Throughout the 360-day treatment period, no herbal tea-related deaths, severe clinical symptoms, loss of body weight, or food intake were seen in any of the treated groups. Bodyweight, food consumption, organ weight, hematological, and serum biochemical findings showed no significant differences between the control and treated groups in both sexes. Macro-pathological and histopathological examinations of the major organs (liver, kidney, heart, pancreas, stomach, and spleen) revealed no herbal tea-related pathologic alterations. </p><p>Conclusion: The findings indicate that long-term (360-days) oral administration of the herbal tea of M. stenopetala and M. spicata leaves blend is well tolerated by rats. Hence, it would be safe/low toxic up to a dose of 2237.44 mg/kg/day in chronic exposure.</p> 
540 |a Copyright © Abdu Hassen Musa et al. 
546 |a en 
655 7 |a Research Article  |2 local 
856 4 1 |u https://doi.org/10.17352/ijpsdr.000038  |z Connect to this object online.