Increased Survival after Treatment of Canine Hemangiosarcoma with Fenofibrate
<p>Hemangiosarcoma (HSA) is a common and highly metastatic tumor that affects predominantly large-breed dogs. The median survival time for dogs diagnosed with splenic HSA without adjuvant chemotherapy after surgery is 86 days. Fenofibrate is an FDA-approved drug commonly utilized to treat high...
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International Journal of Veterinary Science and Research - Peertechz Publications,
2015-10-16.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | peertech__10_17352_ijvsr_000003 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Johanna K Ecke |e author |
| 700 | 1 | 0 | |a Luis Del Valle |e author |
| 700 | 1 | 0 | |a Amanda Parker Struckhoff |e author |
| 700 | 1 | 0 | |a Piotr Waligorski |e author |
| 700 | 1 | 0 | |a Krzysztof Reiss |e author |
| 700 | 1 | 0 | |a Francesca Peruzzi |e author |
| 245 | 0 | 0 | |a Increased Survival after Treatment of Canine Hemangiosarcoma with Fenofibrate |
| 260 | |b International Journal of Veterinary Science and Research - Peertechz Publications, |c 2015-10-16. | ||
| 520 | |a <p>Hemangiosarcoma (HSA) is a common and highly metastatic tumor that affects predominantly large-breed dogs. The median survival time for dogs diagnosed with splenic HSA without adjuvant chemotherapy after surgery is 86 days. Fenofibrate is an FDA-approved drug commonly utilized to treat high cholesterol and high triglyceride levels in humans. However, fenofibrate has also been shown to possess anti-proliferative and anti-metastatic properties against several aggressive and highly metastatic tumors in vitro and in small animal models.We report a case of a 6.5-year-old dog diagnosed with a splenic hemangiosarcoma and treated solely with micronized fenofibrate, administered orally once a day following splenectomy. The dog survived for over 26 months (804 days) after initial diagnosis without signs of adverse effects due to fenofibrate treatment</p> | ||
| 540 | |a Copyright © Johanna K Ecke et al. | ||
| 546 | |a en | ||
| 655 | 7 | |a Case Report |2 local | |
| 856 | 4 | 1 | |u https://doi.org/10.17352/ijvsr.000003 |z Connect to this object online. |