The association between copy number variant of Angiotensin Converting Enzyme gene and the risk of Ascending Aortic Aneurysm in Bicuspid and Tricuspid Aortic Valve
<p><strong>Introduction</strong>: The presence of ACE Insertion/Deletion polymorphism is proposed to be associated with a higher risk for abdominal aortic aneurysm. The aim of this study was to examine a relationship between the occurrence of I/D polymorphism among patients with as...
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| Main Authors: | , , , , , |
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| Format: | Book |
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Journal of Biology and Medicine - Peertechz Publications,
2019-08-20.
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| Online Access: | Connect to this object online. |
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| Summary: | <p><strong>Introduction</strong>: The presence of ACE Insertion/Deletion polymorphism is proposed to be associated with a higher risk for abdominal aortic aneurysm. The aim of this study was to examine a relationship between the occurrence of I/D polymorphism among patients with ascending aortic aneurysm and bicuspid or tricuspid aortic valve structure.</p><p><strong>Material and method</strong>: In this case-control study, 360 patients divided into two groups: 1) patients with ascending aortic aneurysm and bicuspid or tricuspid aortic valve (n= 175), and 2) those without ascending aortic aneurysm as control samples (n=185). The presence of copy number variant (CNV) patterns (Insert/Deletion) of ACE gene was analyzed using real-time polymerase chain reaction.</p> |
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| DOI: | 10.17352/jbm.000015 |