Results of a preliminary study on the effects of a compound on telomeres length, biological and physiological parameters
<p>Telomeres are ribonucleoprotein structures forming a protective buffer at the ends of chromosomes. They preserve the integrity of the genetic material during the cell cycle. Replicative telomere erosion can be compensated by a telomerase. The average size of telomeres is a marker of the bio...
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Journal of Biology and Medicine - Peertechz Publications,
2021-02-17.
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LEADER | 00000 am a22000003u 4500 | ||
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001 | peertech__10_17352_jbm_000025 | ||
042 | |a dc | ||
100 | 1 | 0 | |a Christophe de Jaeger |e author |
700 | 1 | 0 | |a Carla Lamberti |e author |
700 | 1 | 0 | |a Virginie Van Leeuwen |e author |
700 | 1 | 0 | |a Elena Voronska |e author |
700 | 1 | 0 | |a Saskia Kruiskamp |e author |
245 | 0 | 0 | |a Results of a preliminary study on the effects of a compound on telomeres length, biological and physiological parameters |
260 | |b Journal of Biology and Medicine - Peertechz Publications, |c 2021-02-17. | ||
520 | |a <p>Telomeres are ribonucleoprotein structures forming a protective buffer at the ends of chromosomes. They preserve the integrity of the genetic material during the cell cycle. Replicative telomere erosion can be compensated by a telomerase. The average size of telomeres is a marker of the biological age of individuals and their exposure to various physiological and pathological conditions. We are reporting the findings of an open prospective pre-study in healthy volunteers of a new association of molecules on telomere elongation and its cardiovascular action. Ten healthy volunteers (6 men, 4 women), average age 59.4 ± 8.19 years old, with no specific history. This pre-study did reveal significant results concerning the size of the average and median telomeres. The speed of the propagation of the pulse wave on the carotid- femoral and arterial segment shows a reduction (8.74 ± 1.72 m / s at T0 for the 10 subjects, versus 8.18 ± 2.18 at M6). The study shows a significant improvement of the average PAO of 10 subjects, from 1.51 ± 0.13 mmol / l to T0, versus 1.68 ± 0.16 mmol / l at M1 (p <0.0006) and 1.58 ± 0.18 mmol / l at M6 (p <0.05).</p> | ||
540 | |a Copyright © Christophe de Jaeger et al. | ||
546 | |a en | ||
655 | 7 | |a Research Article |2 local | |
856 | 4 | 1 | |u https://doi.org/10.17352/jbm.000025 |z Connect to this object online. |