Adult Granulosa Cell Tumours of the Ovary Seven Case Reports

• Main Authors: Faten LIMAIEM (Author), Saloua MEJRI (Author), Imen KHELIL (Author), Ahlem LAHMAR (Author), Saadia BOURAOUI (Author), Sabeh MZABI-REGAYA (Author)
• Format: Book
• Published: Journal of Gynecological Research and Obstetrics - Peertechz Publications, 2015-12-24.
• Subjects: Review Article
• Online Access: Connect to this object online.

<p><strong>Background:</strong>Ovarian granulosa cell tumours are low-grade malignant sex cord-stromal tumours. They represent 2 to 3% of all ovarian cancers and occur mainly within the adult population. </p><p><strong>Aim:</strong> to provide an updated overview on ovarian adult granulosa cell tumours.Patients <br></p><p> <strong>Methods:</strong>in our retrospective study, we reviewed seven cases of adult granulosa cell tumours that were diagnosed at the pathology department of Mongi Slim hospital over a fourteen-year period (2002- 2015). Clinical and pathRIiological characteristics were retrospectively analyzed.</p><p><strong>Results:</strong> The patients of our series ranged in age between 39 and 64 years (mean = 53 years). The most common presenting symptom was abnormal uterine bleeding (n=5) followed by pelvic pain (n=4). All patients underwent surgical treatment including total hysterectomy with bilateral salpingo-oophorectomy (n=4), hysterectomy with right salpingo-oophorectomy (n=1) and salpingo-oophorectomy (n=2). Histopathological examination of the surgical specimen confirmed the diagnosis of adult granulosa cell tumour in all cases. <strong><br></strong></p><p><strong>Conclusions:</strong>Adult granulosa cell tumours of the ovary are considered as low grade malignancies with a relatively more favourable prognosis compared with much more commonly encountered epithelial ovarian tumours. A prolonged post-therapeutic follow-up is necessary because of the risk of recurrences.</p>