Magnetic Resonance Imaging versus Proton Magnetic Resonance Spectroscopy in Neonatal Hypoxic Ischemic Encephalopathy in Egyptian Population: Pilot study

• Main Authors: Ossama Y Mansour (Author), Doaa Hanfy (Author), Sameh Fathy (Author), Rania E Mohammed (Author)
• Format: Book
• Published: Journal of Neurology, Neurological Science and Disorders - Peertechz Publications, 2017-08-30.
• Subjects: Research Article
• Online Access: Connect to this object online.

Summary

<p><strong>Background</strong>: Hypoxic-ischemic encephalopathy (HIE) is a serious condition that results of critical failure of the intrapartum gas exchange and may lead to a signifi cant damage in the central nervous system.</p><p><strong>Objective</strong>: to elucidate the role of brain magnetic resonance imaging (MRI) versus Proton magnetic resonance spectroscopy (1H-MRS) in the diagnosis and evaluating the severity of HIE in full-term Egyptian neonates</p><p><strong>Design</strong>: 49-months observational controlled study.</p><p><strong>Setting</strong>: Pediatric neurology and Radiology Departments, Alexandria University Hospital        <br></p><p> <strong>Patients and Methods</strong>: Thirty full-term neonates in the fi rst two weeks with HIE (Sarnat staging) were included (18 males and 12 females), with exclusion of those with congenital brain malformation and/ or<br>perinatal infection in addition to 15 age- and sex- matched healthy controls. All patients and controls were<br>examined with brain MRI and 1H-MRS. <br></p><p><strong>Results</strong>: In neonates with HIE, the percent of agreement between clinical staging, and MRI grading<br>was 66.67 while it was 76.67 regarding 1H-MRS grading. The sensitivity for MRI was 66.67%, specifi city<br>was 75%, accuracy was 77.78%, PPV was 80% and NPV was 75%. Meanwhile, the sensitivity for 1H-MRS<br>was 92%, specifi city was 75%, accuracy was 84.44%, PPV was 82.14% and NPV was 88.24%.</p><p><strong>Conclusion</strong>: 1H-MRS detected more percent of agreement, true positive and less false negative cases<br>than MRI. Despite the equal specifi city between them, still 1H-MRS got more sensitivity, accuracy, PPV<br>and NPV than MRI i.e. when we have to choose early and single investigation it is recommended to choose<br>1H-MRS.<strong></strong></p>

DOI

10.17352/jnnsd.000020