To Find out the Essentiality of Rv0526 Gene in Virulence of Mycobacterium tuberculosis by using In silico Approaches
<p>Tuberculosis has emerged as a major world health problem, with almost one-third of the world population today infected with Mycobacterium tuberculosis H37Rv (M. tuberculosis). This gram-positive bacterium makes so many complications in its eradication completely. We need a proper way to inh...
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Open Journal of Bacteriology - Peertechz Publications,
2017-02-11.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | peertech__10_17352_ojb_000003 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Shivangi |e author |
| 700 | 1 | 0 | |a Amjad Beg |e author |
| 700 | 1 | 0 | |a Swati Meena |e author |
| 700 | 1 | 0 | |a Laxman S Meena |e author |
| 245 | 0 | 0 | |a To Find out the Essentiality of Rv0526 Gene in Virulence of Mycobacterium tuberculosis by using In silico Approaches |
| 260 | |b Open Journal of Bacteriology - Peertechz Publications, |c 2017-02-11. | ||
| 520 | |a <p>Tuberculosis has emerged as a major world health problem, with almost one-third of the world population today infected with Mycobacterium tuberculosis H37Rv (M. tuberculosis). This gram-positive bacterium makes so many complications in its eradication completely. We need a proper way to inhibit its pathogenesis. Rv0526 (651bp/ 216 aa) is predicted to be a thioredoxin (Trx) like protein of Rv3673 family form a single transmembrane helix and show similarity to other M. tuberculosis thioredoxin-like proteins Rv1470, Rv1471, Rv1677. Trx are proteins that act as antioxidants by facilitating the reduction of other proteins by cysteine thiol-disulfide exchange, and it acts by its specifi c motif Cys37-Cys40 (CXXC). By using several bioinformatics tools, we may predict that Rv0526 may be an important component of cytochrome c maturation complex and show interaction with different other proteins. After knowing such specifi c features of this gene we may predict that mutational studies in Rv0526 gene may open new way towards the drug development.</p> | ||
| 540 | |a Copyright © Shivangi et al. | ||
| 546 | |a en | ||
| 655 | 7 | |a Review Article |2 local | |
| 856 | 4 | 1 | |u https://doi.org/10.17352/ojb.000003 |z Connect to this object online. |