Microwave Irradated Synthesis, Characterization and Evaluation for their Antibacterial and Larvicidal Activities of some Novel Chalcone and Isoxazole Substituted 9-Anilino Acridines

• Main Authors: R Kalirajan (Author), S Jubie (Author), B Gowramma (Author)
• Format: Book
• Published: Open Journal of Chemistry - Peertechz Publications, 2015-08-27.
• Subjects: Research Article
• Online Access: Connect to this object online.

<p><strong>Introduction:</strong> Chalcone, isoxazole and acridines have diverse biological activities. A series of novel chalcone and isoxazole substituted 9-anilinoacridines were synthesized for their antibacterial, larvicidal, activities.</p><p><strong>Methods: </strong>A series of novel chalcone and isoxazole substituted 9-anilinoacridines (3a-h and 4a-h) were synthesized from 9-chloroacridine by microwave irradiation method. The antibacterial evaluation was performed by cup-plate method and screened for their larvicidal activity by larval bioassay method. Result: The compounds 3d, 3e, 3f, 3h, 4d, 4f have significant antibacterial activity against Gram +ve bacteria like Staphylococcus aureus, Bacillus megaterium, and Gram -ve Escherichia coli, Klebsiella pneumoniae at 25μg/ml. Compounds 3c, 3f, 4a, 4f have significant larvicidal activity against culex and anopheles species at LC50value of 17-36ppm.</p><p><strong>Conclusion: </strong>Many of the compounds have significant antibacterial and larvicidal activities, which are used for further refinement.</p>