Isolated Conjugated Hyperbilirubinemia in Seriously Ill Children - Don't Forget Sepsis!
<p><strong>Background:</strong> Jaundice is frequently associated with extrahepatic systemic infections. The important causes include increased bilirubin levels due to hemolysis, hepatic dysfunction, reduced excretion and cholestasis. Sepsis induced cholestasis has a unique pathoph...
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| Main Authors: | , |
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| Format: | Book |
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Open Journal of Pediatrics and Child Health - Peertechz Publications,
2016-12-06.
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| Online Access: | Connect to this object online. |
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| Summary: | <p><strong>Background:</strong> Jaundice is frequently associated with extrahepatic systemic infections. The important causes include increased bilirubin levels due to hemolysis, hepatic dysfunction, reduced excretion and cholestasis. Sepsis induced cholestasis has a unique pathophysiologic basis. Although common in gram negative sepsis among neonates, the clinical features of sepsis induced cholestasis are not widely recognized older children.</p><p><strong>Case report: </strong>We present a 6 year old, premorbidly asymptomatic boy with community acquired MRSA sepsis-pneumonia and ARDS (Acute respiratory distress syndrome) with isolated conjugated hyperbilirubinemia. A diagnosis of sepsis induced isolated cholestasis was considered after ruling out other possible causes of cholestasis. The hyperbilirubinemia improved with improvement in the primary pathology.</p><p><strong>Conclusion: </strong>Early recognition of sepsis as a cause of isolated cholestatic jaundice would avoid unnecessary investigations and therapy would help in early institution of appropriate therapy.</p> |
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| DOI: | 10.17352/ojpch.000009 |