Divergent Effects of Haloperidol on Motor Versus Spatial Functions
<p>Parkinson's disease causes motor and non-motor deficits mitigated at different degrees with dopamine replacement therapy [1-3]. In addition to the cardinal symptoms of muscle rigidity, akinesia, and resting tremor, patients with Parkinson's disease display postural instabilities....
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Open Journal of Parkinson's Disease and Treatment - Peertechz Publications,
2017-09-20.
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LEADER | 00000 am a22000003u 4500 | ||
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001 | peertech__10_17352_ojpdt_000004 | ||
042 | |a dc | ||
100 | 1 | 0 | |a Robert Lalonde |e author |
700 | 1 | 0 | |a Catherine Strazielle |e author |
245 | 0 | 0 | |a Divergent Effects of Haloperidol on Motor Versus Spatial Functions |
260 | |b Open Journal of Parkinson's Disease and Treatment - Peertechz Publications, |c 2017-09-20. | ||
520 | |a <p>Parkinson's disease causes motor and non-motor deficits mitigated at different degrees with dopamine replacement therapy [1-3]. In addition to the cardinal symptoms of muscle rigidity, akinesia, and resting tremor, patients with Parkinson's disease display postural instabilities. In particular, patients fall more often than controls [4]. More worrisome are the findings that patients' loss in postural control respond poorly to the primary treatment, l-dopa [5], and that l-dopa even impaired some aspects of it [6].</p><p>Motor and non-motor deficits have been reproduced in genetic models of Parkinson's disease [7], or after injections of neurotoxic agents that deplete dopamine concentrations in striatum [8]. Moreover, parkinsonian symptoms appear in schizophrenic subjects after high doses of dopamine-2 (D2) receptor antagonists such as chlorpromazine (CPZ) and haloperidol, to a lesser extent the more selective D4 receptor antagonist, clozapine [9]. In the present study, motor and non-motor effects of haloperidol were examined in mice for exploratory activity in open-field [10], elevated plusmaze [11,12], and emergence [13] tests, motor coordination in stationary beam, coat-hanger, and rotorod [14] tests, and spatial learning in the Morris water maze [15,16].</p> | ||
540 | |a Copyright © Robert Lalonde et al. | ||
546 | |a en | ||
655 | 7 | |a Research Article |2 local | |
856 | 4 | 1 | |u https://doi.org/10.17352/ojpdt.000004 |z Connect to this object online. |