To evaluate the anti-diabetic effects of Salvia cabulica ethanolic extract on alloxan-induced diabetic rabbits

• Main Authors: Abdul Ghaffar (Author), Marvi (Author), Mohammad Younis (Author), Abdul Wahid (Author), Shafi Muhammad (Author), Faisal Ahmed (Author)
• Format: Book
• Published: Open Journal of Pharmacology and Pharmacotherapeutics - Peertechz Publications, 2022-07-19.
• Subjects: Research Article
• Online Access: Connect to this object online.

<p>Objective: This study aimed to investigate the hypoglycemic effects of Salvia cabulica ethanolic extract on alloxan-induced diabetic rabbits. </p><p>Method: During the plant's extraction, the dried plant was soaked in ethanol for 14 days at room temperature and filtered. The dark green gummy filtrate was obtained by using a rotary evaporator at 40oC. Rabbits with fasting glucose levels of more than 250 mg/dL were considered diabetic. These rabbits were treated with aqueous plant extract in different doses (250 mg and 500 mg) respectively. </p><p>Results: The fasting blood glucose level (BGL) mean was 293 ± 25.65 in diabetic control group D-I compared to the normal control group A 99 ± 6.16 after the 48 hours of diabetes induction. The fasting blood glucose level (BGL) in group D-II was 192 ± 17.06, group D-III 93.515.95and group D-IV was 89.33 ± 7.79. </p><p>There was a significant decrease in blood glucose among the group III and IV treated with plant extract at 250 mg/kg and 500 mg/kg, respectively</p><p>Conclusion: The plant Salvia cabulica has potential hypoglycemic activity. Therefore, the medicinal plant can be used as a folklore herbal drug in the treatment of diabetes locally.</p>