No Association of the Complexin-3 Gene Polymorphism with Schizophrenia

<p><strong>Background</strong>: Schizophrenia (SCZ) is a multifactorial mental disease. Whereas complex interplay of genes and environment contributes to the SCZ, the disorder has still unclear biological background. Growing amount of evidence showed that synaptic dysfunctions are...

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Main Authors: Sofi Atshemyan (Author), Roksana Zakharyan (Author), Arsen Arakelyan (Author)
Formato: Livro
Publicado em: Scientific Journal of Genetics and Gene Therapy - Peertechz Publications, 2015-12-30.
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042 |a dc 
100 1 0 |a Sofi Atshemyan  |e author 
700 1 0 |a  Roksana Zakharyan  |e author 
700 1 0 |a  Arsen Arakelyan  |e author 
245 0 0 |a No Association of the Complexin-3 Gene Polymorphism with Schizophrenia 
260 |b Scientific Journal of Genetics and Gene Therapy - Peertechz Publications,   |c 2015-12-30. 
520 |a <p><strong>Background</strong>: Schizophrenia (SCZ) is a multifactorial mental disease. Whereas complex interplay of genes and environment contributes to the SCZ, the disorder has still unclear biological background. Growing amount of evidence showed that synaptic dysfunctions are contributed to SCZ etiopathogenesis.</p><p><strong>The context and purpose of the study</strong>: Complexin-3, a presynaptic regulatory protein, represents here a special interest. This study was aimed to investigate the potential association of SCZ with rs3743487 single nucleotide polymorphism of the complexin-3 protein encoding gene (CPLX3). A total of 350 unrelated individuals of Armenian nationality (175 SCZ patients and the same number of age-, sex-matched healthy controls) were genotyped for the selected polymorphism using polymerase chain reaction with sequence-specific primers.</p><p><strong>Results and main findings</strong>: According to the results obtained, the frequency and carriage of the CPLX3 rs3743487*T allele did not differ in SCZ patients as compared to controls. <strong><br></strong></p><p><strong>Conclusions</strong>: We concluded that the CPLX3 rs3743487*T minor allele is not associated with SCZ in Armenian population.</p><p><strong>Brief summary</strong>: This study suggested no association of the CPLX3 rs3743487 polymorphism with schizophrenia, however, to clarify the role of the CPLX-3 gene in schizophrenia further studies with much coverage of the gene and involvement of different methods are required.</p> 
540 |a Copyright © Sofi Atshemyan et al. 
546 |a en 
655 7 |a Research Article  |2 local 
856 4 1 |u https://doi.org/10.17352/sjggt.000006  |z Connect to this object online.