Comparison of 18F-FDG PET/CT and ceCT Results in the Assessment of RCC Recurrence
<p><strong>Aim: </strong>To compare the results of fl uorine-18 (¹8F) fl uorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) and contrast enhanced computed tomography (ceCT) in the assessment of renal cell carcinoma (RCC) recurrences when ceCT had suspe...
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| Main Authors: | , , , |
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| Format: | Book |
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Studies on Stem Cells Research and Therapy - Peertechz Publications,
2016-12-31.
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| Summary: | <p><strong>Aim: </strong>To compare the results of fl uorine-18 (¹8F) fl uorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) and contrast enhanced computed tomography (ceCT) in the assessment of renal cell carcinoma (RCC) recurrences when ceCT had suspected lesions for local recurrence and/or distant metastases.</p><p><strong>Methods: </strong>A total of 22 patients (14 Male, 8 Female; mean age: 59±9 years) who were referred to perform 18F-FDG PET/CT for restaging of RCC were included in this study. All patients had suspected lesions in thoracal and/or abdominal ceCT for local recurrence and/or distant metastases before PET/CT. A retrospective analysis of the ¹8F-FDG PET/CT results was compared with ceCT results. The compatibility ratios were calculated and accuracy of the 18F-FDG PET/CT was determined. Aggrement between 18F- FDG PET/CT and ceCT was calculated using kappa statistics.</p><p><strong>Results: </strong>The overall concordance rate between the two imaging modalities was 32% (7/22 patients).The rate of concordance for local recurrence was 86% (Kappa:0.67), and for distant metastases was 68% (Kappa:0.40). Distant metastases were also separately investigated and the two imaging methods showed a concordance of 86% (Kappa:0.70) for distant lymph node, 86% (Kappa:0.67) for lung, 91% (Kappa:0.64) for liver and 86% (Kappa:0.33) for bone and 95% for spleen.</p><p><strong>Conclusion: </strong>18F-FDG PET/CT is not enough alone in the detection of local recurrence and distant metastases of RCC. On the other hand, evaluation of 18F-FDG PET/CT and ceCT together signifi cantly improves the detection of RCC recurrence. A negative 18F-FDG PET/CT may contribute to exclusion of suspected metastatic lesions, unless they are milimetric.</p> |
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| DOI: | 10.17352/sscrt.000010 |