Microbial biotransformation of male specific pheromone α-copaene with cunninghamella elegans and antibacterial activity of its transformed products / Syed Adnan Ali Shah ... [et al.]
Pharmaceutical industries are increasingly turning to microbial transformation instead of chemical methods. This is because microbial biotransformation is a more effective way to produce pharmacologically active molecules with high specificity and efficient yield. Additionally, it is a step towards...
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Faculty of Pharmacy,
2023.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | repouitm_86721 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Ali Shah, Syed Adnan |e author |
| 700 | 1 | 0 | |a Atif, Muhammad |e author |
| 700 | 1 | 0 | |a Sultan, Sadia |e author |
| 700 | 1 | 0 | |a Erum, Saira |e author |
| 700 | 1 | 0 | |a Hussain, Samreen |e author |
| 245 | 0 | 0 | |a Microbial biotransformation of male specific pheromone α-copaene with cunninghamella elegans and antibacterial activity of its transformed products / Syed Adnan Ali Shah ... [et al.] |
| 260 | |b Faculty of Pharmacy, |c 2023. | ||
| 500 | |a https://ir.uitm.edu.my/id/eprint/86721/1/86721.pdf | ||
| 520 | |a Pharmaceutical industries are increasingly turning to microbial transformation instead of chemical methods. This is because microbial biotransformation is a more effective way to produce pharmacologically active molecules with high specificity and efficient yield. Additionally, it is a step towards eco-friendly synthesis. α-Copaene (1), a tricyclic sesquiterpene, is a potent attractant of the male Mediterranean fruit fly Ceratitis capitata. This paper presents the utilization of the filamentous fungus Cunninghamella elegans TSY 0865 for large-scale biotransformation of 1. α-Copaene (1) has been incubated with Cunninghamella elegans for 11 days and extracted with CH 2 Cl 2 . Four new hydroxylated metabolites 10,13-dihydroxycopaene (2); 11,13-dihydroxycopaene (3); 11-hydroxycopaen-5-one (4); and 11-hydroxy-13-copaenic acid (5) were afforded. The structures of the new metabolites were elucidated by 1D ( 1 H, 13 C) and 2D NMR (COSY, HMBC, HMQC, and NOESY) techniques and MS analyses. Metabolite 5 exhibited significant antibacterial activity against Bacillus subtilis and Pseudomonas aeruginosa. | ||
| 546 | |a en | ||
| 690 | |a QR Microbiology | ||
| 690 | |a Bacteria | ||
| 655 | 7 | |a Article |2 local | |
| 655 | 7 | |a PeerReviewed |2 local | |
| 787 | 0 | |n https://ir.uitm.edu.my/id/eprint/86721/ | |
| 856 | 4 | 1 | |u https://ir.uitm.edu.my/id/eprint/86721/ |z Link Metadata |