Sintesis Turunan Senyawa Zerumbon 1,2,3-Tris[(1Z,5E,8E)-4',4',8'-Trimetil-7'-Oksosikloundeka-1',5',8'-Trien-1"-Il]Metil 2-Hidroksipropana-1,2,3-Trikarboksilat Dapat Terbentuk Dengan Menggunakan Pereaksi Natrium Sitrat

• Main Authors: Solihin, Muhammad Faid (Author), , Broto Santoso M.Sc., Apt (Author), , Andi Suhendi M.Sc., Apt (Author)
• Format: Book
• Published: 2016-02-10.
• Subjects: Thesis; NonPeerReviewed
• Online Access: Connect to this object online
• Notes: https://eprints.ums.ac.id/41068/1/NASPUB%20MUHAMMAD%20FAID%20SOLIHIN.pdf; https://eprints.ums.ac.id/41068/4/1.%20COVER%20-%20INTISARI.pdf; https://eprints.ums.ac.id/41068/5/2.%20BAB%20I%20PENDAHULUAN.pdf; https://eprints.ums.ac.id/41068/9/3.%20BAB%20II%20METODOLOGI%20PENELITIAN.pdf; https://eprints.ums.ac.id/41068/12/4.%20BAB%20III%20HASIL%20DAN%20PEMBAHASAN.pdf; https://eprints.ums.ac.id/41068/15/5.%20BAB%20IV%20KESIMPULAN%20DAN%20SARAN.pdf; https://eprints.ums.ac.id/41068/18/6.%20DAFTAR%20PUSTAKA.pdf; https://eprints.ums.ac.id/41068/21/7.%20LAMPIRAN.pdf; https://eprints.ums.ac.id/41068/22/SURAT%20PERNYATAAN.pdf
• Keywords: RS Pharmacy and materia medica

Zerumbone including cyclic seskuiterpen which is the active ingredient and the main components as much as 46.83% in the rhizome of lempoyang (Zingiber zerumbet L, Smith) as well as having a variety of biological activities. Synthesis zerumbon derivatives to obtain compounds that have the physical and chemical properties better than the parent compound (zerumbone) without changing the active compound. Zerumbone have the difficult part to be reacted, to increase their reactivity made zerumbone pendan reacted with N-Bromosuccinimide through bromohidroksilasi reaction. Target molecules synthesized by reacting zerumbon pendan (3,0 mmol) with sodium citrate (1.0 mmol) for 16 hours at room temperature. Analysis was performed against the target molecule of the examination of the organoleptic, solubility, TLC profiles, and characterization of 1H and 13C NMR. The results of the analysis of a target molecule obtained yield of 2.27%. Organoleptic examination showed target molecule has better properties than the parent compound in terms of solubility. Characterization of target molecules using nuclear magnetic resonance spectroscopic analysis, shows peaks corresponding to the benchmark zerumbon, citric acid and a compound 6-Asetoksimetil-2,9,9-trimetilsikloundeka-2,6,10-trienon.