Optimasi Formula Sediaan Tablet Getah Tanaman Ashitaba (Angelica Keiskei) Dengan Starch 1500 Sebagai Filler-Binder Dan Explotab Sebagai Penghancur Menggunakan Metode Desain Faktorial
Ashitaba (Angelica keiskei) latex contains 4- Hydroxyderricin component. This component has anti-diabetes activity which implement a mechanism that is similar to insulin mechanism. This study aims to find out the effect of Starch 1500 and Explotab in the formula and to get the optimum formula of Ash...
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2016-06-06.
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| Summary: | Ashitaba (Angelica keiskei) latex contains 4- Hydroxyderricin component. This component has anti-diabetes activity which implement a mechanism that is similar to insulin mechanism. This study aims to find out the effect of Starch 1500 and Explotab in the formula and to get the optimum formula of Ashitaba latex tablets. Optimizing formula was done by using design factorial method with two factors and two levels. Those two factors are Starch 1500 as a filler-binder and Explotab as a disintegrant. The proportion of Starch 1500 and Explotab are FI (25:10); FII (100:10); FIII (25:40); and FIV (100:40). The tablet was made by using wet granulation method. Design Expert software was used to optimize the formula based on the data result evaluation of granule flow rate and tablet physical characteristics. The tablet physical characteristics are flow rate of granules, hardness, fragility, tablets uniformity, and disintegration time. One-sample t-Test was used to compare verification result of optimum formula and prediction formula from Design Expert software. The result of this study showed that high level of Starch 1500 is more dominant improving fragility increase while the high level of Explotab is more dominant to improve reducing the flow rate of granules, to increase CV of weight uniformity, and to reduce disintegration time. Optimum formula obtained the ration of Starch 1500 and Explotab. They are 5% and 8%. |
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| Item Description: | https://eprints.ums.ac.id/44093/17/NASKAH%20PUBLIKASI.pdf https://eprints.ums.ac.id/44093/18/HALAMAN%20DEPAN.pdf https://eprints.ums.ac.id/44093/2/BAB%20I.pdf https://eprints.ums.ac.id/44093/4/BAB%20II.pdf https://eprints.ums.ac.id/44093/6/BAB%20III.pdf https://eprints.ums.ac.id/44093/7/BAB%20IV.pdf https://eprints.ums.ac.id/44093/10/DAFTAR%20PUSTAKA.pdf https://eprints.ums.ac.id/44093/12/LAMPIRAN.pdf https://eprints.ums.ac.id/44093/14/SURAT%20PERNYATAAN%20ARTIKEL%20PUBLIKASI.PDF |