Sitotoksisitas Ekstrak Etanol Kulit Buah Naga (Hylocereus polyrhizus) dan Kulit Pinang (Areca vestiaria) terhadap Sel T47D dengan Metode MTT Assay

• Main Authors: Tanzil, Anna Amalia (Author), , Dr. Haryoto, M.Sc (Author)
• Format: Book
• Published: 2016.
• Subjects: Thesis; NonPeerReviewed
• Online Access: Connect to this object online
• Notes: https://eprints.ums.ac.id/48694/32/Publikasi%20unggah.pdf; https://eprints.ums.ac.id/48694/27/Hal%20Depan.pdf; https://eprints.ums.ac.id/48694/1/Bab%20I.pdf; https://eprints.ums.ac.id/48694/4/Bab%20II.pdf; https://eprints.ums.ac.id/48694/5/Bab%20III.pdf; https://eprints.ums.ac.id/48694/9/Bab%20IV.pdf; https://eprints.ums.ac.id/48694/10/Daftar%20Pustaka.pdf; https://eprints.ums.ac.id/48694/11/Lampiran.pdf; https://eprints.ums.ac.id/48694/30/img007.pdf
• Keywords: RS Pharmacy and materia medica

Dragon fruit (Hylocereus polyrhizus) peels and pinang (Areca vestiaria) known to contain a group of phenolic compounds, flavonoids and alkaloids potentially cytotoxic compounds. This study aimed to determine cytotoxicity dragon fruit peel and pinang. A sample of dragon fruit peels and pinang macerated with 96% ethanol for 3x24 hours, then do evaporation. The yield of the viscous extract obtained from the maceration processed is equal to 17.79% (dragon fruit peel) and 11.11% (nut peel). Both extracts were tested cytotoxicity against T47D cells using MTT method to test parameters such as IC50. IC50 that obtained from each ethanol extract of dragon fruit peel and pinang is >1000 and 661 µg/mL, so it can be concluded that the ethanol extract of dragon fruit peel and pinang does not have a cytotoxic effect against T47D cells.