Pengaruh Pemberian Ekstrak Etanol 70% Daun Binahong (Anredera Cordifolia (Ten.) Steenis) Terhadap Waktu Perdarahan (Bleeding Time) Pada Mencit Jantan Galur Swiss

• Main Authors: Kustriyono, Riani Nazila (Author), , Riandini Aisyah, S.Si, M.Sc (Author)
• Format: Book
• Published: 2017.
• Subjects: Thesis; NonPeerReviewed
• Online Access: Connect to this object online
• Notes: https://eprints.ums.ac.id/50439/23/NASKAH%20PUBLIKASI.pdf; https://eprints.ums.ac.id/50439/4/HALAMAN%20DEPAN.pdf; https://eprints.ums.ac.id/50439/7/BAB%201.pdf; https://eprints.ums.ac.id/50439/8/BAB%202.pdf; https://eprints.ums.ac.id/50439/9/BAB%203.pdf; https://eprints.ums.ac.id/50439/10/BAB%204.pdf; https://eprints.ums.ac.id/50439/11/BAB%205.pdf; https://eprints.ums.ac.id/50439/12/DAFTAR%20PUSTAKA.pdf; https://eprints.ums.ac.id/50439/13/LAMPIRAN.pdf; https://eprints.ums.ac.id/50439/22/SURAT%20PERNYATAAN%20PUBLIKASI%20KARYA%20ILMIAH.pdf
• Keywords: RM Therapeutics. Pharmacology

Background: Binahong leaves contains flavonoids and tanin. Based on theory, flavonoid and tanin have an effect as agent of hemostatics. Objective: This research is aimed to know the effects of 70% ethanol extract of Binahong leaves on bleeding time in male Swiss strain mice. Methods: This research is an experimental laboratory method with Post Test Only With Control Group Design. The animals that used were 25 male Swiss strain mice 2-3 months old, 20-30 g weight, and were divided into 5 groups: negative control, positive control, the first, second and third treatment group. Bleeding time of each group was calculated by using the Duke method. The data was analyzed with one-way ANOVA test and LSD test.Results: The 70% Ethanolic extract of Binahong leaves with concentration of 10%, 15%, and 20% can decrease bleeding time with mean value of bleeding time were 138.60 ± 19,6 seconds, 127.40 ± 13,8 seconds and 108.20 ± 9,4 seconds respectively. One-way ANOVA test showed that there were significantly differences of bleeding time in the five groups after given treatment, p = 0.000 (p<0.05). Conclusion: The 70% Ethanolic extract of Binahong leaves concentrate of 10%, 15%, and 20% shorten bleeding time on male Swiss strain mice. On this research extract with concentrate 20% has the best effect on shorten bleeding time.