EFEKTIVITAS PENGGUNAAN KORTIKOSTEROID TERHADAPPASIEN COVID-19 DERAJAT BERAT DENGAN ARDS: Tinjauan Sistematik

• Main Author: Soraya Maulidina, (Author)
• Format: Book
• Published: 2022-01-12.
• Subjects: Thesis; NonPeerReviewed
• Online Access: Link Metadata

Summary

Introduction: ARDS is a major complication of COVID-19 infection and is associated with a high mortality rate. Currently, no definitive therapy has been shown to reduce ARDS-related mortality with either COVID-19 or non-COVID-19 etiology. The mechanism COVID-19 progresses to ARDS is thought to be due to a cytokine storm. The anti-inflammatory effect of corticosteroids may reduce pulmonary and systemic hyperinflammation due to increased secretion of proinflammatory cytokines. This systematic review will review the effectiveness of using corticosteroids in severe COVID-19 patients with ARDS. Method: A systematic review was conducted by searching the literature on Pubmed and Google Scholar databases with reference to the PRISMA-P method. The literature obtained was then selected through the JBI Critical Appraisal Checklist. Results: administration of corticosteroids with low-high doses of IV methylprednisolone 0.6 - 8 mg/kg/day or high doses of IV dexamethasone 10 - 20 mg/day for 10 days during the early phase of ARDS or risk of developing ARDS (clinical worsening >7 days of onset symptoms) or >72 hours of hospitalization yielded beneficial outcomes in severe COVID-19 patients with ARDS. Corticosteroids were associated with a decreased blood CRP levels, improved ventilation and oxygenation, but did not reduced the risk of mortality and decrease the duration of hospitalization. Conclusion: the use of corticosteroids helps to provide beneficial outcomes in severe COVID-19 patients with ARDS

Item Description

http://repository.upnvj.ac.id/16420/1/ABSTRAK.pdf
http://repository.upnvj.ac.id/16420/13/AWAL.pdf
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http://repository.upnvj.ac.id/16420/4/BAB%202.pdf
http://repository.upnvj.ac.id/16420/6/BAB%203.pdf
http://repository.upnvj.ac.id/16420/5/BAB%204.pdf
http://repository.upnvj.ac.id/16420/7/BAB%205.pdf
http://repository.upnvj.ac.id/16420/8/DAFTAR%20PUSTAKA.pdf
http://repository.upnvj.ac.id/16420/9/RIWAYAT%20HIDUP.pdf
http://repository.upnvj.ac.id/16420/11/LAMPIRAN.pdf
http://repository.upnvj.ac.id/16420/12/HASIL%20PLAGIARISME.pdf
http://repository.upnvj.ac.id/16420/10/ARTIKEL%20KI.pdf