POTENSI DELIMA (PUNICA GRANATUM) SEBAGAI HEPATOPROTEKTOR TERHADAP PERBAIKAN HISTOPATOLOGI HEPAR PADA KEADAAN HEPATOTOKSISITAS IMBAS OBAT SECARA IN VIVO : SYSTEMATIC LITERATURE REVIEW

• Main Author: Marwah Widhawati, (Author)
• Format: Book
• Published: 2022-01-12.
• Subjects: Thesis; NonPeerReviewed
• Online Access: Link Metadata
• Notes: http://repository.upnvj.ac.id/16459/1/ABSTRAK.pdf; http://repository.upnvj.ac.id/16459/13/AWAL.pdf; http://repository.upnvj.ac.id/16459/3/BAB%20I.pdf; http://repository.upnvj.ac.id/16459/4/BAB%20II.pdf; http://repository.upnvj.ac.id/16459/5/BAB%20III.pdf; http://repository.upnvj.ac.id/16459/6/BAB%20IV.pdf; http://repository.upnvj.ac.id/16459/7/BAB%20V.pdf; http://repository.upnvj.ac.id/16459/8/DAFTAR%20PUSTAKA.pdf; http://repository.upnvj.ac.id/16459/9/RIWAYAT%20HIDUP.pdf; http://repository.upnvj.ac.id/16459/10/LAMPIRAN.pdf; http://repository.upnvj.ac.id/16459/11/HASIL%20PLAGIARISME.pdf; http://repository.upnvj.ac.id/16459/12/ARTIKEL%20KI.pdf
• Keywords: R Medicine (General); RB Pathology; RC Internal medicine; RV Botanic, Thomsonian, and eclectic medicine

Background: Consumption of foreign compounds (xenobiotics) can cause drug-induced hepatotoxicity (drug-induced liver injury, DILI). Drug-induced hepatotoxicity is a major cause of acute liver failure and can develop to chronic liver injury and able to become a liver failure. High level of ROS and oxidative stress on DILI can induce cell death as well as increased inflammation. Pomegranate (Punica granatum) as an antioxidant and anti-inflammatory can be an alternative option for DILI treatment. The aim of this study is to assess the potential of pomegranate as a hepatoprotector to improve histopathology of the liver in the state of drug-induced hepatotoxicity in vivo. Methods: A systematic review was done according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols (PRISMA-P) 2015. Database used was PubMed and Google Scholar which discusses about pomegranate, hepatotoxicity, and histopathology. Results: 2 out of 10 journals researched and demonstrated a reduction in apoptosis due to pomegranate administration. 9 out of 10 journals investigated the reduction of necrosis of which 7 of them showed a reduction of necrosis. In addition, of the 10 journals reviewed, 8 of them showed a reduction in inflammatory cell infiltration. Conclusion: Pomegranate contain antioxidant compounds and can function as anti-inflammatory as well as being able to modulate the expression of apoptosis-related proteins potential as hepatoprotector that can improve the histopathological image of the liver in the state of drug-induced hepatotoxicity in vivo in the form of reduction of apoptosis, necrosis, and inflammatory cell infiltration if the dose and time of administration used with the right method.