HUBUNGAN KADAR SERUM ALP DAN KADAR SERUM LDH DENGAN GAMBARAN HISTOPATOLOGI OSTEOSARKOMA DI RSPAD GATOT SOEBROTO PADA PERIODE JANUARI 2016 - SEPTEMBER 2022
Background: Osteosarcoma is one of the most common non-hemopoietic primary bone cancers. Alkaline phosphatase (ALP) is an enzyme that is abundant in osteoblasts and plays a role in the mineralization mechanism of bone formation. In cases of osteosarcoma, ALP will experience an increase due to a high...
Saved in:
| Main Author: | |
|---|---|
| Format: | Book |
| Published: |
2023-01-13.
|
| Subjects: | |
| Online Access: | Link Metadata |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Background: Osteosarcoma is one of the most common non-hemopoietic primary bone cancers. Alkaline phosphatase (ALP) is an enzyme that is abundant in osteoblasts and plays a role in the mineralization mechanism of bone formation. In cases of osteosarcoma, ALP will experience an increase due to a high increase in osteoblastic activity. Lactate dehydrogenase (LDH) is an enzyme that functions in the anaerobic metabolic pathway. In cancer cells, LDH levels have increased because LDH function is modified to increase energy production. The purpose of this study was to determine the relationship between ALP serum levels and LDH serum levels before biopsy with histopathological features in osteosarcoma patients. Methods: This study is a cross-sectional retrospective study conducted at Gatot Soebroto Army Hospital, Jakarta. Data from osteosarcoma patients' medical records were collected from January 2016 to September 2022. Then the data was processed using the chi-square test and logistic regression test. Results: The total sample of the study was 27 patients, and the p-value of ALP with histopathological features was 0.034, OR ALP and histopathological type was 14.793, OR ALP and histopathological grading was 5.867. LDH p-value and histopathological type was 0.239 and LDH p-value and histopathological grading was 0.452). Conclusion: There is a relationship between serum ALP levels and the histopathological features of osteosarcoma, with details of increased serum ALP levels increasing the risk of finding conventional histopathological type osteosarcoma by 14 times and increasing serum ALP levels increasing the risk of finding osteosarcoma with a high degree of malignancy by 5 times. There is no relationship between LDH serum levels and the histopathological features of osteosarcoma. Keywords: osteosarcoma, histopathological type, degree of malignancy, alkaline phosphatase serum, lactate dehydrogenase serum |
|---|---|
| Item Description: | http://repository.upnvj.ac.id/22330/1/ABSTRAK.pdf http://repository.upnvj.ac.id/22330/2/AWAL.pdf http://repository.upnvj.ac.id/22330/3/BAB%20I.pdf http://repository.upnvj.ac.id/22330/4/BAB%20II.pdf http://repository.upnvj.ac.id/22330/5/BAB%20III.pdf http://repository.upnvj.ac.id/22330/6/BAB%20IV.pdf http://repository.upnvj.ac.id/22330/7/BAB%20V.pdf http://repository.upnvj.ac.id/22330/8/DAFTAR%20PUSTAKA.pdf http://repository.upnvj.ac.id/22330/9/RIWAYAT%20HIDUP.pdf http://repository.upnvj.ac.id/22330/14/LAMPIRAN.pdf http://repository.upnvj.ac.id/22330/13/HASIL%20PLAGIARISME.pdf http://repository.upnvj.ac.id/22330/12/ARTIKEL%20KI.pdf |