HISTOPATOLOGI GINJAL PADA PASIEN DENGAN INFEKSI COVID-19: TINJAUAN SYSTEMATIC REVIEW
Coronavirus Disease 2019 (COVID-19) is an infectious disease caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) virus, known to affect not only the respiratory system but also various other organ systems in the body. Currently, there are several studies that have found the ki...
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2021-07-26.
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| Summary: | Coronavirus Disease 2019 (COVID-19) is an infectious disease caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) virus, known to affect not only the respiratory system but also various other organ systems in the body. Currently, there are several studies that have found the kidney to be one of the organs affected, with various patterns of damage observed. This research aims to identify and describe the histopathological patterns of the kidney found in COVID-19 patients. Method: A systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-analyses Protocols (PRISMA-P) guidelines from 2015, with a literature search using the PubMed database. Results: A total of 28 case report articles comprising 35 cases were included. The histopathological patterns of kidney involvement found in COVID-19 patients included collapsing glomerulopathy (57.1%), non-collapsing focal segmental glomerulosclerosis (2.8%), acute tubular injury (54.2%), thrombotic microangiopathy (5.7%), minimal change disease (5.7%), oxidative stress injury (5.7%), membranous nephropathy (2.8%), immune-complex mediated membranoproliferative glomerulonephritis (2.8%), and IgA-Dominant Infection-Associated Glomerulonephritis (2.8%). Conclusion: Kidney damage due to COVID-19 affects all kidney compartments, including the glomerulus, tubulointerstitium, and vascular components. Possible mechanisms that may lead to kidney damage are divided into direct mechanisms involving the virus's direct infection of kidney tissues and indirect mechanisms involving cytokine storms and endothelial dysfunction. Further research is needed to confirm the mechanisms of kidney damage caused by COVID-19. |
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| Item Description: | http://repository.upnvj.ac.id/27304/12/ABSTRAK.pdf http://repository.upnvj.ac.id/27304/2/AWAL.pdf http://repository.upnvj.ac.id/27304/4/BAB%201.pdf http://repository.upnvj.ac.id/27304/5/BAB%202.pdf http://repository.upnvj.ac.id/27304/6/BAB%203.pdf http://repository.upnvj.ac.id/27304/7/BAB%204.pdf http://repository.upnvj.ac.id/27304/8/BAB%205.pdf http://repository.upnvj.ac.id/27304/9/DAFTAR%20PUSTAKA.pdf http://repository.upnvj.ac.id/27304/11/RIWAYAT%20HIDUP.pdf http://repository.upnvj.ac.id/27304/10/LAMPIRAN.pdf http://repository.upnvj.ac.id/27304/3/ARTIKEL%20KI.pdf |