EFEKTIVITAS EKSTRAK TEH HIJAU (Camellia sinensis L.) TERHADAP PENURUNAN KADAR KOLESTEROL TOTAL TIKUS WISTAR (Rattus norvegicus) DIABETES YANG DIINDUKSI ALOKSAN
Green Tea (Camellia sinensis L.) contains flavonoid compounds, works as an anti-dyslipidemia due to chronic hyperglycemia of diabetes. This study aims to determine the effectiveness of green tea extracts on reducing total cholesterol levels in alloxan-induced Wistar diabetic rats. The design of this...
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2020-01-28.
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| 245 | 0 | 0 | |a EFEKTIVITAS EKSTRAK TEH HIJAU (Camellia sinensis L.) TERHADAP PENURUNAN KADAR KOLESTEROL TOTAL TIKUS WISTAR (Rattus norvegicus) DIABETES YANG DIINDUKSI ALOKSAN |
| 260 | |c 2020-01-28. | ||
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| 500 | |a http://repository.upnvj.ac.id/6969/11/ARTIKEL%20KI.pdf | ||
| 520 | |a Green Tea (Camellia sinensis L.) contains flavonoid compounds, works as an anti-dyslipidemia due to chronic hyperglycemia of diabetes. This study aims to determine the effectiveness of green tea extracts on reducing total cholesterol levels in alloxan-induced Wistar diabetic rats. The design of this study is true experimental. Samples were 30 male white Wistar rats, aged 8-12 weeks, weighing ± 200 g. Green tea extract doses of 200, 400, and 800 mg / kg body weight, and negative controls were given alloxan, and positive controls were given simvastatin. The treatment group except the normal group was injected with a dose of 125 mg / kg alloxan intraperitoneally and high-fat feed. After 3 days blood from the tail was measured glucose using a glucometer and cholesterol with a spectrophotometer λ = 546 nm, giving green tea extract for 16 days orally, then re-measuring blood cholesterol from the tail. The paired T test results showed there was a decrease in total cholesterol levels after treatment (p = 0,000). One Way Anova test showed that there was an effectiveness of green tea extract to reduce total cholesterol level (p=0,000). Post-Hoc Bonferroni test results exhibited giving green tea extract a dose of 400 mg / kg comparable to simvastatin (p=0.453) that best for reduce total cholesterol levels close to normal values. | ||
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