PENGARUH PEMBERIAN KORTIKOSTEROID DOSIS RENDAH TERHADAP HITUNG JENIS LEUKOSIT PADA SEPSIS TAHAP AWAL
Early-stage sepsis is characterized by excessive activation of circulating leukocytes, increasing the number of leukocytes exceeding the normal value. Low-dose corticosteroids show significant effects in patients with early-stage sepsis. This study aims to analyze the effect of low-dose corticostero...
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| Format: | Book |
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2020-07-09.
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| Online Access: | Link Metadata |
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| Summary: | Early-stage sepsis is characterized by excessive activation of circulating leukocytes, increasing the number of leukocytes exceeding the normal value. Low-dose corticosteroids show significant effects in patients with early-stage sepsis. This study aims to analyze the effect of low-dose corticosteroids on leukocyte differential count of Balb/C mice in early-stage sepsis. This research type is a true experiment with a post-test only control group research design. The subjects in this study were 30 male Balb/C mice. The sample was randomly divided into 3 groups, which is the control group, the sepsis (cecal inoculum induction) group and the sepsis added with methylprednisolone 1,3 mg/day (equals to 50 mg/day in human) group. The results of the Post-Hoc Bonferroni test of the sepsis group against the control group showed significant differences in the differential count of neutrophils (p=0,009), monocytes (p=0,009) and lymphocytes (p=0,003). The results of the Post-Hoc Bonferroni test of the sepsis group against the sepsis added with low-dose corticosteroids group showed significant differences in the monocyte (p=0,009) and lymphocytes (p=0,046), while neutrophils showed no significant differences of differential count (p=0,100). |
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| Item Description: | http://repository.upnvj.ac.id/7731/1/ABSTRAK.pdf http://repository.upnvj.ac.id/7731/12/AWAL.pdf http://repository.upnvj.ac.id/7731/3/BAB%201.pdf http://repository.upnvj.ac.id/7731/4/BAB%202.pdf http://repository.upnvj.ac.id/7731/13/BAB%203.pdf http://repository.upnvj.ac.id/7731/6/BAB%204.pdf http://repository.upnvj.ac.id/7731/7/BAB%205.pdf http://repository.upnvj.ac.id/7731/8/DAFTAR%20PUSTAKA.pdf http://repository.upnvj.ac.id/7731/9/DAFTAR%20RIWAYAT%20HIDUP.pdf http://repository.upnvj.ac.id/7731/14/LAMPIRAN.pdf http://repository.upnvj.ac.id/7731/11/ARTIKEL%20KI.pdf |