Search Results - "BRD4"

BRD4 Targets the KEAP1-Nrf2-G6PD Axis and Suppresses Redox Metabolism in Small Cell Lung Cancer by Yang Lv, Xiaotong Lv, Jiahui Zhang, Guozhen Cao, Changzhi Xu, Buchang Zhang, Wenchu Lin

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circNR3C1 Suppresses Bladder Cancer Progression through Acting as an Endogenous Blocker of BRD4/C-myc Complex by Fei Xie, Xingyuan Xiao, Dan Tao, Chao Huang, Liang Wang, Feng Liu, Hui Zhang, Haitao Niu, Guosong Jiang

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7-Ethyl-10-Hydroxycamptothecin, a DNA Topoisomerase I Inhibitor, Performs BRD4 Inhibitory Activity and Inhibits Human Leukemic Cell Growth by Airong Wang, Lingling Li, Mengya Li, Shujuan Wang, Chong Wang

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Transcriptome-Based Co-Expression of BRD4 and PD-1/PD-L1 Predicts Poor Overall Survival in Patients With Acute Myeloid Leukemia by Cunte Chen, Ling Xu, Ling Xu, Rili Gao, Shunqing Wang, Yuping Zhang, Caixia Wang, Chengwu Zeng, Yangqiu Li

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Splice‐switch oligonucleotide‐based combinatorial platform prioritizes synthetic lethal targets CHK1 and BRD4 against MYC‐driven hepatocellular carcinoma by Dexter Kai Hao Thng, Tan Boon Toh, Paolo Pigini, Lissa Hooi, Yock Young Dan, Pierce Kah‐Hoe Chow, Glenn Kunnath Bonney, Masturah Bte Mohd Abdul Rashid, Ernesto Guccione, Dave Keng Boon Wee, Edward Kai‐Hua Chow

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Corrigendum: 7-Ethyl-10-Hydroxycamptothecin, A DNA Topoisomerase I Inhibitor, Performs BRD4 Inhibitory Activity and Inhibits Human Leukemic Cell Growth by Airong Wang, Lingling Li, Mengya Li, Shujuan Wang, Chong Wang

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Concurrent targeting of MAP3K3 and BRD4 by miR-3140-3p overcomes acquired resistance to BET inhibitors in neuroblastoma cells by Chang Liu, Yasuyuki Gen, Kousuke Tanimoto, Tomoki Muramatsu, Jun Inoue, Johji Inazawa

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PP 1.24 - 00132 BET PROTACS Reveal BRD4 Disruption of the 7SK/P-TEFb Equilibrium is Critical for Effective Reactivation of Latent HIV in CD4+ T-cells by A-M. Turner, F. Potjewyd, S. Falcinelli, J. Fox, J. Kirchherr, B. Allard, N. Archin, L. James, D. Margolis

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Novel Aminopyrimidine-2,4-diones, 2-Thiopyrimidine-4-ones, and 6-Arylpteridines as Dual-Target Inhibitors of BRD4/PLK1: Design, Synthesis, Cytotoxicity, and Computational Studies by Samar El-Kalyoubi, Samiha A. El-Sebaey, Sherin M. Elfeky, Hanan A. AL-Ghulikah, Mona S. El-Zoghbi

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Design, synthesis, and evaluation of 4-(3-(3,5-dimethylisoxazol-4-yl)benzyl)phthalazin-1(2H)-one derivatives: potent BRD4 inhibitors with anti-breast cancer activity by Yingpeng Li, Xinhong Chu, Yu Yin, Hongkun Li, Hui Fu, Xinchi Feng, Yanru Deng, Jun Ge

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A commentary on "PI3K‐α/mTOR/BRD4 inhibitor alone or in combination with other anti‐virals blocks replication of SARS‐CoV‐2 and its variants of concern including Delta and Omicron" by Sakthijothi Muthu, Sundararajan Venkatesh

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Molecular Pathways in Cancers

Subjects: “…pBRD4…”
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Apabetalone, a BET protein inhibitor, inhibits kidney damage in diabetes by preventing pyroptosis via modulating the P300/H3K27ac/PLK1 axis by Min Wang, Zhaohui Huang, Xin Li, Ping He, He Sun, Yali Peng, QiuLing Fan

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Design, synthesis, and biological evaluation of quinazolin-4(3H)-one derivatives co-targeting poly(ADP-ribose) polymerase-1 and bromodomain containing protein 4 for breast cancer t... by Xiaosa Chang, Dejuan Sun, Danfeng Shi, Guan Wang, Yanmei Chen, Kai Zhang, Huidan Tan, Jie Liu, Bo Liu, Liang Ouyang

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Gene-repressing epigenetic reader EED unexpectedly enhances cyclinD1 gene activation by Mengxue Zhang, Jing Li, Qingwei Wang, Go Urabe, Runze Tang, Yitao Huang, Jose Verdezoto Mosquera, K. Craig Kent, Bowen Wang, Clint L. Miller, Lian-Wang Guo

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Mechanistic Analysis of Chemically Diverse Bromodomain-4 Inhibitors Using Balanced QSAR Analysis and Supported by X-ray Resolved Crystal Structures by Magdi E. A. Zaki, Sami A. Al-Hussain, Aamal A. Al-Mutairi, Vijay H. Masand, Abdul Samad, Rahul D. Jawarkar

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BET Bromodomain Degradation Disrupts Function but Not 3D Formation of RNA Pol2 Clusters by Diana H. Chin, Issra Osman, Jadon Porch, Hyunmin Kim, Kristen K. Buck, Javier Rodriguez, Bianca Carapia, Deborah Yan, Stela B. Moura, Jantzen Sperry, Jonathan Nakashima, Kasey Altman, Delsee Altman, Berkley E. Gryder

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Design and Synthesis of Hybrid Compounds as Epigenetic Modifiers by Juliana Romano Lopes, Igor Muccilo Prokopczyk, Max Gerlack, Chung Man Chin, Jean Leandro Dos Santos

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Development of hedgehog pathway inhibitors by epigenetically targeting GLI through BET bromodomain for the treatment of medulloblastoma by Xiaohua Liu, Yu Zhang, Yalei Li, Juan Wang, Huaqian Ding, Wenjing Huang, Chunyong Ding, Hongchun Liu, Wenfu Tan, Ao Zhang

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Targeting inducible epigenetic reprogramming pathways in chronic airway remodeling by Allan R Brasier, Istvan Boldogh

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