Search Results - "Huntington disease"

The Novel Alpha-2 Adrenoceptor Inhibitor Beditin Reduces Cytotoxicity and Huntingtin Aggregates in Cell Models of Huntington's Disease by Elisabeth Singer, Lilit Hunanyan, Magda M. Melkonyan, Jonasz J. Weber, Lusine Danielyan, Huu Phuc Nguyen

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Design, Characterization, and Lead Selection of Therapeutic miRNAs Targeting Huntingtin for Development of Gene Therapy for Huntington's Disease by Jana Miniarikova, Ilaria Zanella, Angelina Huseinovic, Tom van der Zon, Evelyn Hanemaaijer, Raygene Martier, Annemart Koornneef, Amber L Southwell, Michael R Hayden, Sander J van Deventer, Harald Petry, Pavlina Konstantinova

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Focused Ultrasound-Mediated Disruption of the Blood-Brain Barrier for AAV9 Delivery in a Mouse Model of Huntington's Disease by Bernie S. Owusu-Yaw, Yongzhi Zhang, Lilyan Garrett, Alvin Yao, Kai Shing, Ana Rita Batista, Miguel Sena-Esteves, Jaymin Upadhyay, Kimberly Kegel-Gleason, Nick Todd

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Deterioration of mitochondrial bioenergetics and ultrastructure impairment in skeletal muscle of a transgenic minipig model in the early stages of Huntington's disease by Marie Rodinova, Jana Krizova, Hana Stufkova, Bozena Bohuslavova, Georgina Askeland, Zaneta Dosoudilova, Stefan Juhas, Jana Juhasova, Zdenka Ellederova, Jiri Zeman, Lars Eide, Jan Motlik, Hana Hansikova

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Effect of Shorea robusta resin extract in 3-nitropropionic acid-induced Huntington's disease symptoms in Sprague-Dawley rats by Chirag Patel, Khushboo Thakur, Lalita Shagond, Sanjeev Acharya, Ketan Ranch, Sai HS Boddu

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A Remote Digital Monitoring Platform to Assess Cognitive and Motor Symptoms in Huntington Disease: Cross-sectional Validation Study by Florian Lipsmeier, Cedric Simillion, Atieh Bamdadian, Rosanna Tortelli, Lauren M Byrne, Yan-Ping Zhang, Detlef Wolf, Anne V Smith, Christian Czech, Christian Gossens, Patrick Weydt, Scott A Schobel, Filipe B Rodrigues, Edward J Wild, Michael Lindemann

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Modulation of SETDB1 activity by APQ ameliorates heterochromatin condensation, motor function, and neuropathology in a Huntington's disease mouse model by Yu Jin Hwang, Seung Jae Hyeon, Younghee Kim, Sungsu Lim, Min Young Lee, Jieun Kim, Ashwini M. Londhe, Lizaveta Gotina, Yunha Kim, Ae Nim Pae, Yong Seo Cho, Jihye Seong, Hyemyung Seo, Yun Kyung Kim, Hyunah Choo, Hoon Ryu, Sun-Joon Min

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CRISPR-Cas9-Mediated Genome Editing Increases Lifespan and Improves Motor Deficits in a Huntington's Disease Mouse Model by Freja K. Ekman, David S. Ojala, Maroof M. Adil, Paola A. Lopez, David V. Schaffer, Thomas Gaj

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A CAG repeat-targeting artificial miRNA lowers the mutant huntingtin level in the YAC128 model of Huntington's disease by Anna Kotowska-Zimmer, Lukasz Przybyl, Marianna Pewinska, Joanna Suszynska-Zajczyk, Dorota Wronka, Maciej Figiel, Marta Olejniczak

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Patient-Specific iPSC-Based Models of Huntington's Disease as a Tool to Study Store-Operated Calcium Entry Drug Targeting by Vladimir Vigont, Evgeny Nekrasov, Alexey Shalygin, Konstantin Gusev, Sergey Klushnikov, Sergey Illarioshkin, Maria Lagarkova, Maria Lagarkova, Sergey L. Kiselev, Elena Kaznacheyeva

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Spatiotemporal Up-Regulation of Mu Opioid Receptor 1 in Striatum of Mouse Model of Huntington's Disease Differentially Affecting Caudal and Striosomal Regions by Ryoma Morigaki, Ryoma Morigaki, Ryoma Morigaki, Ryoma Morigaki, Jannifer H. Lee, Jannifer H. Lee, Jannifer H. Lee, Jannifer H. Lee, Tomoko Yoshida, Tomoko Yoshida, Christian Wüthrich, Christian Wüthrich, Dan Hu, Dan Hu, Jill R. Crittenden, Jill R. Crittenden, Jill R. Crittenden, Alexander Friedman, Alexander Friedman, Yasuo Kubota, Yasuo Kubota, Ann M. Graybiel, Ann M. Graybiel

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Theoretical design for covering Engeletin with functionalized nanostructure-lipid carriers as neuroprotective agents against Huntington's disease via the nasal-brain route by Smriti, Madhav Singla, Saurabh Gupta, Omji Porwal, Dalal Nasser Binjawhar, Amany A. Sayed, Pooja Mittal, Fatma M. El-Demerdash, Mohammad Algahtani, Sachin Kumar Singh, Sachin Kumar Singh, Kamal Dua, Kamal Dua, Kamal Dua, Gaurav Gupta, Gaurav Gupta, Puneet Bawa, Ahmed E. Altyar, Ahmed E. Altyar, Mohamed M. Abdel-Daim, Mohamed M. Abdel-Daim

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Huntington disease iPSCs show early molecular changes in intracellular signaling, the expression of oxidative stress proteins and the p53 pathway by Wojciech J. Szlachcic, Pawel M. Switonski, Wlodzimierz J. Krzyzosiak, Marek Figlerowicz, Maciej Figiel

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miR-196a enhances polymerization of neuronal microfilaments through suppressing IMP3 and upregulating IGF2 in Huntington's disease by Han-In Yang, Pin-Yu Huang, Siew Chin Chan, Chih-Wei Tung, Pei-Hsun Cheng, Chuan-Mu Chen, Shang-Hsun Yang

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Genome-wide significance for a modifier of age at neurological onset in Huntington's Disease at 6q23-24: the HD MAPS study by Gillis Tammy, Mysore Jayalakshmi, Djoussé Luc, Xu Gang, Prakash Ranjana, Wheeler Vanessa C, Lazzarini Alice, Ashizawa Tetsuo, Jones Randi, Paulsen Jane S, Frontali Marina, Novelletto Andrea, McCusker Elizabeth, Trent Ronald JA, Klimek Mary, Suchowersky Oksana, García Carmen, Gómez-Tortosa Estrella, Frati Luigi, Squitieri Ferdinando, Rosenblatt Adam, Margolis Russell L, Ross Christopher A, Nance Martha, Morrison Patrick J, Durr Alexandra, Warby Simon C, Hayden Michael R, Li Jian-Liang, Hakky Michael, Cupples L Adrienne, Saint-Hilaire Marie H, Cha Jang-Ho J, Hersch Steven M, Penney John B, Harrison Madaline B, Perlman Susan L, Zanko Andrea, Abramson Ruth K, Lechich Anthony J, Duckett Ayana, Marder Karen, Conneally P Michael, Gusella James F, MacDonald Marcy E, Myers Richard H

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Rapid and high-purity differentiation of human medium spiny neurons reveals LMNB1 hypofunction and subtype necessity in modeling Huntington's disease by Junjiao Wu, Jie Ren, Hongfei Cui, Yali Xie, Yu Tang

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Selective Sparing of Striatal Interneurons after Poly (ADP-Ribose) Polymerase 1 Inhibition in the R6/2 Mouse Model of Huntington's Disease by Emanuela Paldino, Antonella Cardinale, Vincenza D'Angelo, Ilaria Sauve, Carmela Giampà, Carmela Giampà, Francesca R. Fusco

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A Combinatorial Cell and Drug Delivery Strategy for Huntington's Disease Using Pharmacologically Active Microcarriers and RNAi Neuronally-Committed Mesenchymal Stromal Cells by Emilie M. André, Gaëtan J. Delcroix, Saikrishna Kandalam, Laurence Sindji, Claudia N. Montero-Menei

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Neuroprotective potency of mangiferin against 3-nitropropionic acid induced Huntington's disease-like symptoms in rats: possible antioxidant and anti-inflammatory mechanisms by Pei Teng Lum, Mahendran Sekar, Lay Jing Seow, Mohd Farooq Shaikh, Mohd Farooq Shaikh, Alina Arulsamy, Thaarvena Retinasamy, Siew Hua Gan, Charles Gnanaraj, Norhaizan Mohd Esa, Gobinath Ramachawolran, Vetriselvan Subramaniyan, Vetriselvan Subramaniyan, Suresh V. Chinni, Suresh V. Chinni, Yuan Seng Wu

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Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Protects Striatal Cells and Improves Motor Function in Huntington's Disease Models: Role of PAC1 Receptor by Irene Solés-Tarrés, Núria Cabezas-Llobet, Benjamin Lefranc, Benjamin Lefranc, Jérôme Leprince, Jérôme Leprince, Jordi Alberch, Jordi Alberch, Jordi Alberch, David Vaudry, David Vaudry, Xavier Xifró

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