Search Results - "Liver"

Antisense RNA Design, Delivery, and Analysis

Table of Contents: “…Introduction and History of the Chemistry of Nucleic Acids Therapeutics -- Antisense RNA Therapeutics: A Brief Overview -- Design of Bifunctional Antisense Oligonucleotides for Exon Inclusion -- Design and Delivery of SINEUP: A New Modular Tool to Increase Protein Translation -- How to Design U1 snRNA Molecules for Splicing Rescue -- Conjugation of Nucleic Acids and Drugs to Gold Nanoparticles -- Determination of Optimum Ratio of Cationic Polymers and Small Interfering RNA with Agarose Gel Retardation Assay -- Generation of Protein-Phosphorodiamidate Morpholino Oligomer Conjugates for Efficient Cellular Delivery via Anthrax Protective Antigen -- Development and Use of Cellular Systems to Assess and Correct Splicing Defects -- Modeling Splicing Variants Amenable to Antisense Therapy by Use of CRISPR-Cas9-Based Gene Editing in HepG2 Cells -- In Vitro Models for the Evaluation of Antisense Oligonucleotides in Skin -- In Vitro Delivery of PMOs in Myoblasts by Electroporation -- Rapid Determination of MBNL1 Protein Levels by Quantitative Dot Blot for Evaluation of Antisense Oligonucleotides in Myotonic Dystrophy Myoblasts -- Evaluation of Exon Skipping and Dystrophin Restoration in In Vitro Models of Duchenne Muscular Dystrophy -- Generation of Human iPSC-Derived Myotubes to Investigate RNA-Based Therapies In Vitro -- Eye on a Dish Models to Evaluate Splicing Modulation -- Establishment of In Vitro Brain Models for AON Delivery -- Considerations for Generating Humanized Mouse Models to Test Efficacy of Antisense Oligonucleotides -- Generation of Humanized Zebrafish Models for the In Vivo Assessment of Antisense Oligonucleotide-Based Splice Modulation Therapies -- Use of Small Animal Models for Duchenne and Parameters to Assess Efficiency upon Antisense Treatment -- In Vivo Models for the Evaluation of Antisense Oligonucleotides in Skin -- Delivery of Antisense Oligonucleotides to the Mouse Retina -- Delivery of Antisense Oligonucleotides to the Mouse Brain by Intracerebroventricular Injections -- Intrathecal Delivery of Therapeutic Oligonucleotides for Potent Modulation of Gene Expression in the Central Nervous System -- Preclinical Safety Assessment of Therapeutic Oligonucleotides -- Preclinical Evaluation of the Renal Toxicity of Oligonucleotide Therapeutics in Mice -- Protocol for Isolation and Culture of Mouse Hepatocytes (HCs), Kupffer Cells (KCs), and Liver Sinusoidal Endothelial Cells (LSECs) in Analyses of Hepatic Drug Distribution -- Patent Considerations When Embarking on New Antisense Drug Programs.…”
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Fibroblast Growth Factor 21 Ameliorates NaV1.5 and Kir2.1 Channel Dysregulation in Human AC16 Cardiomyocytes by Jiamin Li, Jiamin Li, Yuanshi Li, Yining Liu, Yining Liu, Hang Yu, Hang Yu, Ning Xu, Ning Xu, Di Huang, Di Huang, Yadong Xue, Yadong Xue, Sijia Li, Sijia Li, Haixin Chen, Haixin Chen, Jiali Liu, Jiali Liu, Qingsui Li, Qingsui Li, Yiming Zhao, Yiming Zhao, Ronghao Zhang, Ronghao Zhang, Hongru Xue, Hongru Xue, Yuehang Sun, Yuehang Sun, Ming Li, Ming Li, Pengyu Li, Pengyu Li, Mingbin Liu, Mingbin Liu, Zhen Zhang, Zhen Zhang, Xin Li, Xin Li, Weijie Du, Weijie Du, Ning Wang, Ning Wang, Baofeng Yang, Baofeng Yang

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Validating anti-inflammatory and cytotoxic properties of Fagonia cretica L. through metabolic, in vitro, and in silico profiling by Enas I. A. Mohamed, Ahlam H. Elwekeel, Dalia El Amir Mohamed, Mohamed A. Zaki, Marwa H. A. Hassan

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The Pharmacognostic Research of L. luteus L. by O. V. Grechana

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Evaluation of Alectinib Metabolic Stability in HLMs Using Fast LC-MS/MS Method: In Silico ADME Profile, P450 Metabolic Lability, and Toxic Alerts Screening by Mohamed W. Attwa, Haitham AlRabiah, Gamal A. E. Mostafa, Adnan A. Kadi

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The study of serum c-reactive protein/albumin ratio as a prognostic marker in patients with sepsis and septic shock in a tertiary care hospital by H A Krishnamurthy, U Kishor

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The Role of Pharmacogenomics Studies for Precision Medicine Among Ethiopian Patients and Their Clinical Implications: A Scoping Review by Getahun KA, Angaw DA, Asres MS, Kahaliw W, Petros Z, Abay SM, Yimer G, Berhane N

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Eggshell membrane hydrolyzates activate NF-κB in vitro: possible implications for in vivo efficacy by Ruff KJ, Durham PL, O’Reilly A, Long FD

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Prevalência dos fatores trombofílicos em mulheres com infertilidade Prevalence of thrombophilic factors in infertile women by Adriana de Góes e Silva Soligo, Ricardo Barini, Egle Cristina Couto de Carvalho, Joyce Annichino-Bizzacchi

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Cholesterol absorption blocker ezetimibe prevents muscle wasting in severe dysferlin‐deficient and mdx mice by Zoe White, Marine Theret, Nadia Milad, Lin Wei Tung, William Wei‐Han Chen, Martin G. Sirois, Fabio Rossi, Pascal Bernatchez

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Glucagon-like peptide-2 promotes gallbladder refilling via a TGR5-independent, GLP-2R-dependent pathway by Bernardo Yusta, Dianne Matthews, Grace B. Flock, John R. Ussher, Brigitte Lavoie, Gary M. Mawe, Daniel J. Drucker

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Clinical, microbiological and pathological findings of Mycobacterium ulcerans infection in three Australian Possum species. by Carolyn R O'Brien, Kathrine A Handasyde, Jennifer Hibble, Caroline J Lavender, Alistair R Legione, Christina McCowan, Maria Globan, Anthony T Mitchell, Helen E McCracken, Paul D R Johnson, Janet A M Fyfe

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Metabolomics-based discovery of XHP as a CYP3A4 inhibitor against pancreatic cancer by Yuting Yang, Yuting Yang, Yanlei Guo, Hua Luo, Menglei Wang, Fang Chen, Huawei Cui, Ping Chen, Zhujun Yin, Li Li, Ying Dai, Jin Zeng, Junning Zhao, Junning Zhao

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Combination Therapy of Cuban Policosanol (Raydel^®, 20 mg) and Intensive Exercise for 12 Weeks Resulted in Improvements in Obesity, Hypertension, and Dyslipidemia without... by Kyung-Hyun Cho, Hyo-Seon Nam, Na-Young Kim, Myeong-Sung Lee, Dae-Jin Kang

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Role of interleukin 6 polymorphism and inflammatory markers in outcome of pediatric Covid- 19 patients by Reem A. AbdelAziz, Samir Tamer Abd-Allah, Hend M. Moness, Ahmed M. Anwar, Zamzam Hassan Mohamed

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Mycosis Fungoides: A Diagnostic Challenge by Siddhartha Nath, Arunima Dhabal, Indrashis Podder

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Safety and efficacy of oil palm phenolic supplementation in improving lipid profile among hyperlipidemic adults: a phase 2, randomized, double-blind, placebo-controlled clinical tr... by Nur Balqis Muhammad Ismail Tadj, Nurul `Izzah Ibrahim, Tg Mohd Ikhwan Tg Abu Bakar Sidik, Mohamed S. Zulfarina, Qodriyah Haji Mohd Saad, Soon-Sen Leow, Syed Fairus, Isa Naina Mohamed

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Mortality and causes of death in people diagnosed with HIV in the era of highly active antiretroviral therapy compared with the general population: an analysis of a national observ... by Sara Croxford, MSc, Aileen Kitching, MFPH, Sarika Desai, MSc, Meaghan Kall, MSc, Michael Edelstein, MFPH, Andrew Skingsley, MRCP, Fiona Burns, FRCP, Andrew Copas, PhD, Alison E Brown, PhD, Ann K Sullivan, FRCP, Valerie Delpech, FPHM

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Antimicrobial Peptide Cec4 Eradicates Multidrug-Resistant Acinetobacter baumannii in vitro and in vivo by Peng J, Wang Y, Wu Z, Mao C, Li L, Cao H, Qiu Z, Guo G, Liang G, Shen F

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How Frequently Does out-of Hospital Sudden Unexpected Infants Death Represent the Sudden Infant Death Syndrome? by Lika L. Nisevich, Oleg V. Krieger, Natalia S. Selyutina, Stanislav Y. Bernikov, Tatyana N. Konopleva, Igor N. Nikishtsev, Marina S. Pavlova

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