Search Results - "Medicinal Chemistry"

Dual targeting of cancer-related human matrix metalloproteinases and carbonic anhydrases by chiral N-(biarylsulfonyl)-phosphonic acids by Grazia Luisi, Guido Angelini, Carla Gasbarri, Antonio Laghezza, Mariangela Agamennone, Fulvio Loiodice, Claudiu T. Supuran, Cristina Campestre, Paolo Tortorella

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Biochemical profiling of anti-HIV prodrug Elsulfavirine (Elpida®) and its active form VM1500A against a panel of twelve human carbonic anhydrase isoforms by Claudiu T. Supuran, Alessio Nocentini, Elena Yakubova, Nikolay Savchuk, Stanislav Kalinin, Mikhail Krasavin

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Optimisation of novel 4, 8-disubstituted dihydropyrimido[5,4-b][1,4]oxazine derivatives as potent GPR 119 agonists by Yuanying Fang, Shaokun Zhang, Min Li, Lijuan Xiong, Liangxing Tu, Saisai Xie, Yi Jin, Yanhua Liu, Zunhua Yang, Ronghua Liu

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Druggable cavities and allosteric modulators of the cell division cycle 7 (CDC7) kinase by Elisa Rojas-Prats, Loreto Martinez-Gonzalez, Carmen Gil, David Ramírez, Ana Martinez

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Recent advances in natural products targeting α-synuclein aggregation or clearance in Parkinson's disease by Jay Gupta, Koneni V. Sashidhara

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From the Discovery of Targets to Delivery Systems: How to Decipher and Improve the Metallodrugs' Actions at a Molecular Level by Ilaria Iacobucci, Sara La Manna, Irene Cipollone, Vittoria Monaco, Luisa Canè, Flora Cozzolino

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In vitro anticancer potentiality and molecular modelling study of novel amino acid derivatives based on N1,N3-bis-(1-hydrazinyl-1-oxopropan-2-yl) isophthalamide by Asmaa F. Kassem, Gaber O. Moustafa, Eman S. Nossier, Hemat S. Khalaf, Marwa M. Mounier, Suliman A. Al-Yousef, Sabry Y. Mahmoud

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Insights into the role of reactive sulfhydryl groups of Carbonic Anhydrase III and VII during oxidative damage by Daria M. Monti, Giuseppina De Simone, Emma Langella, Claudiu T. Supuran, Anna Di Fiore, Simona M. Monti

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The use of dimethylsulfoxide as a solvent in enzyme inhibition studies: the case of aldose reductase by Livia Misuri, Mario Cappiello, Francesco Balestri, Roberta Moschini, Vito Barracco, Umberto Mura, Antonella Del-Corso

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Myeloperoxidase, a possible biomarker for the early diagnosis of cardiac diastolic dysfunction with preserved ejection fraction by Bogdan Ioan Coculescu, Gabi Valeriu Dincă, Constantin Bălăeţ, Gheorghe Manole, Maria Bălăeţ, Cristina Mariana Stocheci

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Selective inhibition of carbonic anhydrase IX and XII by coumarin and psoralen derivatives by Rita Meleddu, Serenella Deplano, Elias Maccioni, Francesco Ortuso, Filippo Cottiglia, Daniela Secci, Alessia Onali, Erica Sanna, Andrea Angeli, Rossella Angius, Stefano Alcaro, Claudiu T. Supuran, Simona Distinto

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In vitro and in vivo antitumour effects of phenylboronic acid against mouse mammary adenocarcinoma 4T1 and squamous carcinoma SCCVII cells by Maja Marasovic, Sinisa Ivankovic, Ranko Stojkovic, Damir Djermic, Borivoj Galic, Mladen Milos

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Carbazole scaffolds in cancer therapy: a review from 2012 to 2018 by Samar Issa, Anthony Prandina, Nicolas Bedel, Pål Rongved, Saïd Yous, Marc Le Borgne, Zouhair Bouaziz

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Synthesis of biologically active sulfonamide-based indole analogs: a review by Irfan Mushtaq, Adnan Ahmed

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Discovery of small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase by Supreet Kaur, Nicholas S. Nieto, Peter McDonald, Josh R. Beck, Richard B. Honzatko, Anuradha Roy, Scott W. Nelson

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Chemoinformatics Strategies for Leishmaniasis Drug Discovery by Leonardo L. G. Ferreira, Adriano D. Andricopulo

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Biotin conjugates in targeted drug delivery: is it mediated by a biotin transporter, a yet to be identified receptor, or (an)other unknown mechanism(s)? by Ravi Tripathi, Anchala Guglani, Rujuta Ghorpade, Binghe Wang

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Probing the druggability of membrane-bound Rab5 by molecular dynamics simulations by Eileen Edler, Matthias Stein

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Development of a novel, high-affinity ssDNA trypsin inhibitor by Stanislaw Malicki, Miroslaw Ksiazek, Pawel Majewski, Aleksandra Pecak, Piotr Mydel, Przemyslaw Grudnik, Grzegorz Dubin

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Comprehensive Insights into Medicinal Research on Imidazole-Based Supramolecular Complexes by Shu-Rui Li, Yi-Min Tan, Ling Zhang, Cheng-He Zhou

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