Search Results - "Medicinal Chemistry"

Inhibition of α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae with aromatic sulphonamides and clinically licenced drugs - a joint docking/molecular d... by Alessandro Bonardi, Alessio Nocentini, Sameh Mohamed Osman, Fatmah Ali Alasmary, Tahani Mazyad Almutairi, Dalal Saied Abdullah, Paola Gratteri, Claudiu T. Supuran

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Darunavir ethanolate: Repurposing an anti-HIV drug in COVID-19 treatment by Vivek P. Chavda, Normi Gajjar, Nirav Shah, Divyang J. Dave

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Simultaneous administration of EZH2 and BET inhibitors inhibits proliferation and clonogenic ability of metastatic prostate cancer cells by Aide Negri, Marina Marozzi, Daniela Trisciuoglio, Dante Rotili, Antonello Mai, Federica Rizzi

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4-(3-Alkyl/benzyl-guanidino)benzenesulfonamides as selective carbonic anhydrase VII inhibitors by Morteza Abdoli, Simone Giovannuzzi, Claudiu T. Supuran, Raivis Žalubovskis

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Quinoxaline 1, 4-di-N-oxides: Biological activities and mechanisms of actions by Guyue eCheng, Wei eSa, Chen eCao, Liangliang eGuo, Haihong eHao, Zhenli eLiu, Xu eWang, Zonghui eYuan

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Inhibitory prodrug mechanism for cysteine cathepsin-targeted self-controlled drug release by Floris J. van Dalen, Martijn Verdoes

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Carbonic anhydrase inhibition with a series of novel benzenesulfonamide-triazole conjugates by Marwa G. El-Gazzar, Nessma H. Nafie, Alessio Nocentini, Mostafa M. Ghorab, Helmi I. Heiba, Claudiu T. Supuran

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Synthesis and in vitro and in vivo anti-inflammatory activity of novel 4-ferrocenylchroman-2-one derivatives by Wei-Yun Guo, Liu-Zeng Chen, Bang-Nian Shen, Xin-Hua Liu, Guang-Ping Tai, Qing-Shan Li, Li Gao, Ban-Feng Ruan

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Identification of putative allosteric inhibitors of BCKDK via virtual screening and biological evaluation by Chunqiong Li, Quanjun Yang, Li Zhang

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Structure-activity exploration of a small-molecule allosteric inhibitor of T790M/L858R double mutant EGFR by Francesca Foschi, Annachiara Tinivella, Valentina Crippa, Luca Pinzi, Luca Mologni, Daniele Passarella, Giulio Rastelli

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A comprehensive investigation of the anion inhibition profile of a β-carbonic anhydrase from Acinetobacter baumannii for crafting innovative antimicrobial treatments by Viviana De Luca, Simone Giovannuzzi, Claudiu T. Supuran, Clemente Capasso

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Potent carbonic anhydrase I, II, IX and XII inhibition activity of novel primary benzenesulfonamides incorporating bis-ureido moieties by Tuba Tekeli, Suleyman Akocak, Andrea Petreni, Nebih Lolak, Servet Çete, Claudiu T. Supuran

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Sulphonamide inhibition profile of Staphylococcus aureus β-carbonic anhydrase by Linda J. Urbanski, Silvia Bua, Andrea Angeli, Marianne Kuuslahti, Vesa. P. Hytönen, Claudiu T. Supuran, Seppo Parkkila

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Design of a multi-target focused library for antidiabetic targets using a comprehensive set of chemical transformation rules by Fernanda I. Saldívar-González, Gabriel Navarrete-Vázquez, José L. Medina-Franco

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Oxy-imino saccharidic derivatives as a new structural class of aldose reductase inhibitors endowed with anti-oxidant activity by Felicia D'Andrea, Stefania Sartini, Ilaria Piano, Matteo Franceschi, Luca Quattrini, Lorenzo Guazzelli, Lidia Ciccone, Elisabetta Orlandini, Claudia Gargini, Concettina La Motta, Susanna Nencetti

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Discovery of novel dual inhibitors of receptor tyrosine kinases EGFR and IGF-1R by Cornelius Hempel, Frank Totzke, Christoph Schächtele, Abdulkarim Najjar, Wolfgang Sippl, Christoph Ritter, Andreas Hilgeroth

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Lavandula angustifolia mill. (Lamiaceae) ethanol extract and its main constituents as promising agents for the treatment of metabolic disorders: chemical profile, in vitro biologic... by Rosa Tundis, Fedora Grande, Maria A. Occhiuzzi, Vincenzo Sicari, Monica R. Loizzo, Anna R. Cappello

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Novel series of 1,2,4-trioxane derivatives as antimalarial agents by Mithun Rudrapal, Dipak Chetia, Vineeta Singh

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Human carboxylesterases: a comprehensive review by Dandan Wang, Liwei Zou, Qiang Jin, Jie Hou, Guangbo Ge, Ling Yang

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Synthesis, biological evaluation and molecular modelling of 2,4-disubstituted-5-(6-alkylpyridin-2-yl)-1H-imidazoles as ALK5 inhibitors by Myoung-Soon Park, Hyun-Ju Park, Young Jae An, Joon Hun Choi, Geunyoung Cha, Hwa Jeong Lee, So-Jung Park, Purushottam M. Dewang, Dae-Kee Kim

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