Search Results - "Medicinal Chemistry"

Interaction of letrozole and its degradation products with aromatase: chemometric assessment of kinetics and structure-based binding validation by Michele De Luca, Maria Antonietta Occhiuzzi, Bruno Rizzuti, Giuseppina Ioele, Gaetano Ragno, Antonio Garofalo, Fedora Grande

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Development of terphenyl-2-methyloxazol-5(4H)-one derivatives as selective reversible MAGL inhibitors by Carlotta Granchi, Isabella Caligiuri, Eleonora Bertelli, Giulio Poli, Flavio Rizzolio, Marco Macchia, Adriano Martinelli, Filippo Minutolo, Tiziano Tuccinardi

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Evaluation of the anticancer potential of a sulphonamide carbonic anhydrase IX inhibitor on cervical cancer cells by Ismail Koyuncu, Yasin Tülüce, Hewa Slahaddin Qadir, Mustafa Durgun, Claudiu T. Supuran

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From the Wuhan-Hu-1 strain to the XD and XE variants: is targeting the SARS-CoV-2 spike protein still a pharmaceutically relevant option against COVID-19? by Matteo Pavan, Davide Bassani, Mattia Sturlese, Stefano Moro

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9,10-Dioxoanthracenyldithiocarbamates effectively inhibit the proliferation of non-small cell lung cancer by targeting multiple protein tyrosine kinases by Mateusz Olszewski, Maryna Stasevych, Viktor Zvarych, Natalia Maciejewska

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New insight into structure-activity of furan-based salicylate synthase (MbtI) inhibitors as potential antitubercular agents by Laurent R. Chiarelli, Matteo Mori, Giangiacomo Beretta, Arianna Gelain, Elena Pini, Josè Camilla Sammartino, Giovanni Stelitano, Daniela Barlocco, Luca Costantino, Margherita Lapillo, Giulio Poli, Isabella Caligiuri, Flavio Rizzolio, Marco Bellinzoni, Tiziano Tuccinardi, Stefania Villa, Fiorella Meneghetti

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White-to-Beige and Back: Adipocyte Conversion and Transcriptional Reprogramming by Stanislav Boychenko, Vera S. Egorova, Andrew Brovin, Alexander D. Egorov

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Screening of ninety herbal products of commercial interest as potential ingredients for phytocosmetics by Mariacaterina Lianza, Manuela Mandrone, Ilaria Chiocchio, Paola Tomasi, Lorenzo Marincich, Ferruccio Poli

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Design, synthesis and evaluation of 2, 6, 8-substituted Imidazopyridine derivatives as potent PI3Kα inhibitors by Rui Chen, Zhongyuan Wang, Lijie Sima, Hu Cheng, Bilan Luo, Jianta Wang, Bing Guo, Shunyi Mao, Zhixu Zhou, Jingang Peng, Lei Tang, Xinfu Liu, Weike Liao

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Design, synthesis and biological evaluation of 2,4-pyrimidinediamine derivatives as ALK and HDACs dual inhibitors for the treatment of ALK addicted cancer by Dafeng Guo, Yu Yu, Binyu Long, Ping Deng, Dongzhi Ran, Lei Han, Jiecheng Zheng, Zongjie Gan

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Benzo[b]tiophen-3-ol derivatives as effective inhibitors of human monoamine oxidase: design, synthesis, and biological activity by Paolo Guglielmi, Daniela Secci, Anél Petzer, Donatella Bagetta, Paola Chimenti, Giulia Rotondi, Claudio Ferrante, Lucia Recinella, Sheila Leone, Stefano Alcaro, Gokhan Zengin, Jacobus P. Petzer, Francesco Ortuso, Simone Carradori

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Design, synthesis, and biological evaluation of biotinylated colchicine derivatives as potential antitumor agents by Chao Wang, Yujing Zhang, Zeyu Wang, Yuelin Li, Qi Guan, Dongming Xing, Weige Zhang

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Discovery of new butyrylcholinesterase inhibitors via structure-based virtual screening by Noor Atatreh, Sara Al Rawashdah, Shaikha S. Al Neyadi, Sawsan M. Abuhamdah, Mohammad A. Ghattas

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Design, synthesis and antitumor activity of 5-trifluoromethylpyrimidine derivatives as EGFR inhibitors by Yaqing Zuo, Rongrong Li, Yan Zhang, Guochen Bao, Yi Le, Longjia Yan

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Synthesis and anticancer properties of celastrol derivatives involved in the inhibition of VEGF by Mingxia Song, Jiantao Wen, Yi Hua, Yangnv Zhu, Qishan Xia, Qiaoyue Guo, Yiqin Luo, Xianqing Deng, Yushan Huang

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Ligand-based discovery of coronavirus main protease inhibitors using MACAW molecular embeddings by Jie Dong, Mihayl Varbanov, Stéphanie Philippot, Fanny Vreken, Wen-bin Zeng, Vincent Blay

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Design and characterisation of piperazine-benzofuran integrated dinitrobenzenesulfonamide as Mycobacterium tuberculosis H37Rv strain inhibitors by Vallabhaneni S. Murthy, Yasinalli Tamboli, Vagolu Siva Krishna, Dharmarajan Sriram, Siddique Akber Ansari, Abdullah A. Alarfaj, Abdurahman H. Hirad, Vijayaparthasarathi Vijayakumar

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Histidine residues at the copper-binding site in human tyrosinase are essential for its catalytic activities by Hyangsoon Noh, Sung Jun Lee, Hyun-Joo Jo, Hye Won Choi, Sungguan Hong, Kwang-Hoon Kong

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Inhibition of Toxoplasma gondii by 1,2,4-triazole-based compounds: marked improvement in selectivity relative to the standard therapy pyrimethamine and sulfadiazine by Lidia Węglińska, Adrian Bekier, Nazar Trotsko, Barbara Kaproń, Tomasz Plech, Katarzyna Dzitko, Agata Paneth

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Selenium-analogs based on natural sources as cancer-associated carbonic anhydrase isoforms IX and XII inhibitors by Nora Astrain-Redin, Niccolò Paoletti, Daniel Plano, Alessandro Bonardi, Paola Gratteri, Andrea Angeli, Carmen Sanmartin, Claudiu T. Supuran

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