Search Results - "Medicinal Chemistry"

Synthesis and human carbonic anhydrase I, II, VA, and XII inhibition with novel amino acid-sulphonamide conjugates by Hasan Küçükbay, Nesrin Buğday, F. Zehra Küçükbay, Andrea Ageli, Gianluca Bartolucci, Claudiu T. Supuran

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Rational design of small molecules able to inhibit α-synuclein amyloid aggregation for the treatment of Parkinson's disease by Serena Vittorio, Ilenia Adornato, Rosaria Gitto, Samuel Peña-Díaz, Salvador Ventura, Laura De Luca

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Discovery of novel paeonol-based derivatives against skin inflammation in vitro and in vivo by Jing Wu, Ren De Zhu, Guo Min Cao, Jun Cheng Du, Xin Liu, Liang Zhuo Diao, Zhao Yan Zhang, Yang Sheng Hu, Xin Hua Liu, Jing Bo Shi

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Ethenesulfonyl fluoride derivatives as telomerase inhibitors: structure-based design, SAR, and anticancer evaluation in vitro by Xing Chen, Gao-Feng Zha, Jie Quan Wang, Xin-Hua Liu

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The RFK catalytic cycle of the pathogen Streptococcus pneumoniae shows species-specific features in prokaryotic FMN synthesis by María Sebastián, Adrián Velázquez-Campoy, Milagros Medina

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Insights into the inhibitory activities of neolignans and diarylnonanoid derivatives from nutmeg (Myristica fragrans Houtt.) seeds on soluble epoxide hydrolase using in vitro and i... by Vu Thi Oanh, Nguyen Viet Phong, Byung Sun Min, Seo Young Yang, Jeong Ah Kim

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Vanillin enones as selective inhibitors of the cancer associated carbonic anhydrase isoforms IX and XII. The out of the active site pocket for the design of selective inhibitors? by Leonardo E. Riafrecha, Macarena S. Le Pors, Martín J. Lavecchia, Silvia Bua, Claudiu T. Supuran, Pedro A. Colinas

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First studies on tumor associated carbonic anhydrases IX and XII monoclonal antibodies conjugated to small molecule inhibitors by Chiara Testa, Anna Maria Papini, Reinhard Zeidler, Daniela Vullo, Fabrizio Carta, Claudiu T. Supuran, Paolo Rovero

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Evolution of the Quinoline Scaffold for the Treatment of Leishmaniasis: A Structural Perspective by Carlos F. M. Silva, Diana C. G. A. Pinto, Pedro A. Fernandes, Artur M. S. Silva

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Synthesis carbonic anhydrase enzyme inhibition and antioxidant activity of novel benzothiazole derivatives incorporating glycine, methionine, alanine, and phenylalanine moieties by Deniz Üzeroğlu Payaz, F. Zehra Küçükbay, Hasan Küçükbay, Andrea Angeli, Claudiu T. Supuran

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Antitumor properties of certain spirooxindoles towards hepatocellular carcinoma endowed with antioxidant activity by Sara T. Al-Rashood, Ahmed R. Hamed, Ghada S. Hassan, Hamad M. Alkahtani, Abdulrahman A. Almehizia, Amal Alharbi, Mohammad M. Al-Sanea, Wagdy M. Eldehna

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LC-QTOF-MS analysis of xanthone content in different parts of Garcinia mangostana and its influence on cholinesterase inhibition by Kooi Yeong Khaw, Chun Wie Chong, Vikneswaran Murugaiyah

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Peptide foldamer-based inhibitors of the SARS-CoV-2 S protein-human ACE2 interaction by Violeta Marković, Jeelan Basha Shaik, Katarzyna Ożga, Agnieszka Ciesiołkiewicz, Juan Lizandra Perez, Ewa Rudzińska-Szostak, Łukasz Berlicki

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Isothiocyanates: cholinesterase inhibiting, antioxidant, and anti-inflammatory activity by Franko Burčul, Ivana Generalić Mekinić, Mila Radan, Patrick Rollin, Ivica Blažević

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Strained contacts with the cell membrane may influence ligand affinity to G protein coupled receptors: a case of free fatty acid receptor 1 agonists by Alexey Lukin, Anna Bakholdina, Mikhail Chudinov, Oleksandra Onopchenko, Elena Zhuravel, Sergey Zozulya, Maxim Gureev, Mikhail Krasavin

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N-isopropyl-(4-methoxy-3-difluoromethyl)cinnamoyl amide targets mycobacterial MmpL3 by Mario D. Martínez, Liliana Rondón, Lisandro Ronconi, Mariano Prado Acosta, Agostina Crotta Asis, Gabriela Gago, Florencia Di Salvo, Gerardo Burton, Fernando Durán, Mariana Piuri

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Dapagliflozin: A new hope for the therapeutic treatment of type 2 diabetes mellitus by Naazneen Maksud, Sidhant Bera, Mohd Javed Naim, Ozair Alam

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Design, synthesis and antifungal activity of threoninamide carbamate derivatives via pharmacophore model by Xiu-Jiang Du, Xing-Jie Peng, Rui-Qi Zhao, Wei-Guang Zhao, Wei-Li Dong, Xing-Hai Liu

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Antiproliferative effects of sulphonamide carbonic anhydrase inhibitors C18, SLC-0111 and acetazolamide on bladder, glioblastoma and pancreatic cancer cell lines by Silvia Mussi, Sara Rezzola, Paola Chiodelli, Alessio Nocentini, Claudiu T. Supuran, Roberto Ronca

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Structure activity relationship of the binding of p-coumaroyl glucose to glycogen phosphorylase and its effect on hepatic cell metabolic pathways by Anastasia S. Tsagkarakou, Styliani A. Chasapi, Symeon M. Koulas, Ioannis Tsialtas, Efthimios Kyriakis, Christina E. Drakou, Sándor Kun, László Somsák, Georgios A. Spyroulias, Anna-Maria G. Psarra, Demetres D. Leonidas

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