Search Results - "Medicinal Chemistry"

CAIX furthers tumour progression in the hypoxic tumour microenvironment of esophageal carcinoma and is a possible therapeutic target by Astrid Drenckhan, Morton Freytag, Claudiu T. Supuran, Guido Sauter, Jakob R. Izbicki, Stephanie J. Gros

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Synthesis and identification of GZD856 as an orally bioavailable Bcr-AblT315I inhibitor overcoming acquired imatinib resistance by Xiaoyun Lu, Zhang Zhang, Xiaomei Ren, Deping Wang, Ke Ding

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Discovery and antitumor evaluation of novel inhibitors of spermine oxidase by Lidan Sun, Jianlin Yang, Yu Qin, Yanlin Wang, Hongyan Wu, You Zhou, Chunyu Cao

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Latency, thermal stability, and identification of an inhibitory compound of mirolysin, a secretory protease of the human periodontopathogen Tannerella forsythia by Krzysztof M. Zak, Mark J. Bostock, Irena Waligorska, Ida B. Thøgersen, Jan J. Enghild, Grzegorz M. Popowicz, Przemyslaw Grudnik, Jan Potempa, Miroslaw Ksiazek

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Novel temporin L antimicrobial peptides: promoting self-assembling by lipidic tags to tackle superbugs by Rosa Bellavita, Annarita Falanga, Elisabetta Buommino, Francesco Merlino, Bruno Casciaro, Floriana Cappiello, Maria Luisa Mangoni, Ettore Novellino, Maria Rosaria Catania, Rossella Paolillo, Paolo Grieco, Stefania Galdiero

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Novel 2-phenoxypyrido[3,2-b]pyrazin-3(4H)-one derivatives as potent and selective aldose reductase inhibitors with antioxidant activity by Xin Hao, Gang Qi, Hongxing Ma, Changjin Zhu, Zhongfei Han

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Design, synthesis and evaluation of carbazole derivatives as potential antimicrobial agents by Yi-Jie Xue, Ming-Yue Li, Xue-Jun Jin, Chang-Ji Zheng, Hu-Ri Piao

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Pharmacophore-based discovery of 2-(phenylamino)aceto-hydrazides as potent eosinophil peroxidase (EPO) inhibitors by Daniela Schuster, Martina Zederbauer, Thierry Langer, Andreas Kubin, Paul G. Furtmüller

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Novel Chemical Scaffolds to Inhibit the Neutral Amino Acid Transporter B0AT1 (SLC6A19), a Potential Target to Treat Metabolic Diseases by Aditya Yadav, Nishank Shah, Praveen Kumar Tiwari, Kiran Javed, Qi Cheng, Indrapal Singh Aidhen, Stefan Bröer

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Therapeutic potential of natural compounds for treatment of chronic obstructive pulmonary disease: Current status and future perspective by Sanjeev Kumar Sahu, MD Musarraf Rain, Manish Vyas

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Synthesis of Flavonoids or Other Nature-Inspired Small Molecules

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Structure-guided approach on the role of substitution on amide-linked bipyrazoles and its effect on their anti-inflammatory activity by Souraya A. Domiati, Khaled H. Abd El Galil, Mohammed A. S. Abourehab, Tamer M. Ibrahim, Hanan M. Ragab

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Novel anti-inflammatory and analgesic agents: synthesis, molecular docking and in vivo studies by David Izuchukwu Ugwu, Uchechukwu Christopher Okoro, Pius Onyeoziri Ukoha, Astha Gupta, Sunday N. Okafor

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Development of novel salicylic acid-donepezil-rivastigmine hybrids as multifunctional agents for the treatment of Alzheimer's disease by Yi Zhou, Ying He, Xue Teng, Jing Mi, Jing Yang, Rongrui Wei, Wenmin Liu, Qinge Ma, Zhenghuai Tan, Zhipei Sang

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Delivery of N-heterocyclic drugs, acids, phenols, and thiols via Tailor−made Self−immolative linkers by Vahid Barati, Anna Hruzíková, Eliška Procházková, Martin Zavřel, Jaroslav Kozák, Jana Trylčová, Dominik Rejman, Jan Weber, Kateřina Bogdanová, Milan Kolář, Ondřej Baszczyňski

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Computer-aided molecular design of pyrazolotriazines targeting glycogen synthase kinase 3 by M. Lourdes Sciú, Victor Sebastián-Pérez, Loreto Martinez-Gonzalez, Rocio Benitez, Daniel I. Perez, Concepción Pérez, Nuria E. Campillo, Ana Martinez, E. Laura Moyano

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Identification of new allosteric sites and modulators of AChE through computational and experimental tools by Carlos Roca, Carlos Requena, Víctor Sebastián-Pérez, Sony Malhotra, Chris Radoux, Concepción Pérez, Ana Martinez, Juan Antonio Páez, Tom L. Blundell, Nuria E. Campillo

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Exposure of human intestinal epithelial cells and primary human hepatocytes to trypsin-like serine protease inhibitors with potential antiviral effect by Erzsébet Pászti-Gere, Judit Pomothy, Ákos Jerzsele, Oliver Pilgram, Torsten Steinmetzer

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Seeking new approach for therapeutic treatment of cholera disease via inhibition of bacterial carbonic anhydrases: experimental and theoretical studies for sixteen benzenesulfonami... by Rosaria Gitto, Laura De Luca, Francesca Mancuso, Sonia Del Prete, Daniela Vullo, Claudiu T. Supuran, Clemente Capasso

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Bisindolyl Maleimides and Indolylmaleimide Derivatives-A Review of Their Synthesis and Bioactivity by Louise N. Cooney, Kevin D. O'Shea, Hannah J. Winfield, Michael M. Cahill, Larry T. Pierce, Florence O. McCarthy

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