Search Results - "Medicinal Chemistry"

Structure-guided design of anti-cancer ribonucleotide reductase inhibitors by Tessianna A. Misko, Yi-Ting Liu, Michael E. Harris, Nancy L. Oleinick, John Pink, Hsueh-Yun Lee, Chris G. Dealwis

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Technologies for Direct Detection of Covalent Protein-Drug Adducts by Elma Mons, Robbert Q. Kim, Monique P. C. Mulder

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Synthesis and biological evaluation of novel 8-substituted quinoline-2-carboxamides as carbonic anhydrase inhibitors by Pavitra S. Thacker, Pirpasha Shaikh, Andrea Angeli, Mohammed Arifuddin, Claudiu T. Supuran

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Discovery of talmapimod analogues as polypharmacological anti-inflammatory agents by Wandong Liu, Caiyun Hou, Jiaming Li, Xiaodong Ma, Yanchun Zhang, Mengqi Hu, Yuanzheng Huang

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Identifying requirements for RSK2 specific inhibitors by Eric B. Wright, Shinji Fukuda, Mingzong Li, Yu Li, George A. O'Doherty, Deborah A. Lannigan

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Discovery of aminopyridine-containing spiro derivatives as EGFR mutations inhibitors by Lianbao Ye, Tao Zhao, Wenjun Du, Anhu Li, Wei Gao, Jingrong Li, Ling Wang, Weiqiang Chen

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Evaluation of mode of indoleamine 2,3-dioxygenase 1 inhibition by 4,7-dichloroquinolines by Niku Moni Das, Biswa Mohan Prusty, Nirmalya Pradhan, Anjali Gupta, Miguel Carmena-Bargueño, Rama Karn, Horacio Pérez-Sánchez, Sachin Kumar, Debasis Manna

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Inhibitors of phosphoinositide 3-kinase (PI3K) and phosphoinositide 3-kinase-related protein kinase family (PIKK) by Xueqin Huang, Li You, Eugenie Nepovimova, Miroslav Psotka, David Malinak, Marian Valko, Ladislav Sivak, Jan Korabecny, Zbynek Heger, Vojtech Adam, Qinghua Wu, Kamil Kuca

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Structure-activity relationship studies for inhibitors for vancomycin-resistant Enterococcus and human carbonic anhydrases by Weiwei An, Katrina J. Holly, Alessio Nocentini, Ryan D. Imhoff, Chad. S. Hewitt, Nader S. Abutaleb, Xufeng Cao, Mohamed N. Seleem, Claudiu T. Supuran, Daniel P. Flaherty

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Coumarins effectively inhibit bacterial α-carbonic anhydrases by Simone Giovannuzzi, Chad S. Hewitt, Alessio Nocentini, Clemente Capasso, Daniel P. Flaherty, Claudiu T. Supuran

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Reactive oxygen species inhibit catalytic activity of peptidylarginine deiminase by Dres Damgaard, Mads Emil Bjørn, Peter Østrup Jensen, Claus Henrik Nielsen

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Novel multitarget-directed tacrine derivatives as potential candidates for the treatment of Alzheimer's disease by Wen-Yu Wu, Yu-Chen Dai, Nian-Guang Li, Ze-Xi Dong, Ting Gu, Zhi-Hao Shi, Xin Xue, Yu-Ping Tang, Jin-Ao Duan

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Therapeutic role of flavonoids and flavones in cancer prevention: Current trends and future perspectives by Azhar U. Khan, Hanuman S. Dagur, Masudulla Khan, Nazia Malik, Mahboob Alam, Md Mushtaque

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Design, synthesis and biological evaluation of carbohydrate-based sulphonamide derivatives as topical antiglaucoma agents through selective inhibition of carbonic anhydrase II by Zhuang Hou, Chuanchao Li, Yichuang Liu, Miao Zhang, Yitong Wang, Zhanfang Fan, Chun Guo, Bin Lin, Yang Liu

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Synthesis and biological assessment of indole derivatives containing penta-heterocycles scaffold as novel anticancer agents towards A549 and K562 cells by Guanglong Zhang, Zhenhua Tang, Sili Fan, Chengpeng Li, Yan Li, Weiqin Liu, Xuesha Long, Wenjing Zhang, Yi Zhang, Zhurui Li, Zhenchao Wang, Danping Chen, Guiping Ouyang

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A potentiated cooperation of carbonic anhydrase IX and histone deacetylase inhibitors against cancer by Jessica Ruzzolini, Anna Laurenzana, Elena Andreucci, Silvia Peppicelli, Francesca Bianchini, Fabrizio Carta, Claudiu T. Supuran, Maria Novella Romanelli, Chiara Nediani, Lido Calorini

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Metal complexes of saccharin and thiosaccharin as potential anticancer and antimicrobial agents by Ceyda Icsel, Veysel T. Yilmaz, Okan Z. Yesilel, William T.A. Harrison

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Comprehensive review of DNA gyrase as enzymatic target for drug discovery and development by K. Rajakumari, K. Aravind, M. Balamugundhan, Manjunathan Jagadeesan, Ambiga Somasundaram, Parthiban Brindha Devi, Pasiyappazham Ramasamy

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Conjugation as a Tool in Therapeutics: Role of Amino Acids/Peptides-Bioactive (Including Heterocycles) Hybrid Molecules in Treating Infectious Diseases by Rohith Gattu, Sanjay S. Ramesh, Siddaram Nadigar, Channe Gowda D, Suhas Ramesh

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Design, synthesis, and in vitro evaluation of aza-peptide aldehydes and ketones as novel and selective protease inhibitors by Thomas S. Corrigan, Leilani M. Lotti Diaz, Sarah E. Border, Steven C. Ratigan, Kayla Q. Kasper, Daniel Sojka, Pavla Fajtova, Conor R. Caffrey, Guy S. Salvesen, Craig A. McElroy, Christopher M. Hadad, Özlem Doğan Ekici

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