Search Results - "Medicinal Chemistry"

Exploring of N-phthalimide-linked 1,2,3-triazole analogues with promising ­anti-SARS-CoV-2 activity: synthesis, biological screening, and molecular modelling studies by Ateyatallah Aljuhani, Mosa Alsehli, Mohamed A. Seleem, Shaya Y. Alraqa, Hany E. A. Ahmed, Nadjet Rezki, Mohamed R. Aouad

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Stereoselective pharmacokinetic and pharmacodynamic analysis of a CNS-active sulphamoylphenyl carbamate derivative by David Bibi, Bella Shusterman, Alessio Nocentini, Claudiu T. Supuran, Meir Bialer

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Anion inhibition studies of a beta carbonic anhydrase from the malaria mosquito Anopheles gambiae by Daniela Vullo, Leo Syrjänen, Marianne Kuuslahti, Seppo Parkkila, Claudiu T. Supuran

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Combining nano-differential scanning fluorimetry and microscale thermophoresis to investigate VDAC1 interaction with small molecules by Hubert Gorny, Angélique Mularoni, Jean-Guy Delcros, Céline Freton, Jordane Preto, Isabelle Krimm

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Novel tetrazole and cyanamide derivatives as inhibitors of cyclooxygenase-2 enzyme: design, synthesis, anti-inflammatory evaluation, ulcerogenic liability and docking study by Phoebe F. Lamie, John N. Philoppes, Amany A. Azouz, Nesreen M. Safwat

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Evaluation of polyphenols from Broussonetia papyrifera as coronavirus protease inhibitors by Ji-Young Park, Heung Joo Yuk, Hyung Won Ryu, Su Hwan Lim, Kyung Su Kim, Ki Hun Park, Young Bae Ryu, Woo Song Lee

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Chemistry-led investigations into the mode of action of NAMPT activators, resulting in the discovery of non-pyridyl class NAMPT activators by Siyuan Tang, Miguel Garzon Sanz, Oliver Smith, Andreas Krämer, Daniel Egbase, Paul W. Caton, Stefan Knapp, Sam Butterworth

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Identification of the first-in-class dual inhibitors of human DNA topoisomerase IIα and indoleamine-2,3-dioxygenase 1 (IDO 1) with strong anticancer properties by Barbara Kaproń, Anita Płazińska, Wojciech Płaziński, Tomasz Plech

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Non-covalent immunoproteasome inhibitors induce cell cycle arrest in multiple myeloma MM.1R cells by Roberta Ettari, Giovanni Pallio, Gabriele Pizzino, Natasha Irrera, Maria Zappalà, Santina Maiorana, Carla Di Chio, Domenica Altavilla, Francesco Squadrito, Alessandra Bitto

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Synthesis and biological evaluation of novel (E)-N'-benzylidene hydrazides as novel c-Met inhibitors through fragment based virtual screening by Jing-wei Liang, Shi-long Li, Shan Wang, Wan-qiu Li, Fan-hao Meng

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A convenient total synthesis of PSMA-617: A prostate specific membrane antigen (PSMA) ligand for prostate cancer endotherapeutic applications by K.S. Ajish Kumar, Anupam Mathur

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Salvinorin A, a kappa-opioid receptor (KOP-r) agonist hallucinogen: Pharmacology and potential template for novel pharmacotherapeutic agents in neuropsychiatric disorders by Eduardo eButelman, Mary Jeanne eKreek

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Synthesis and anti-hepatocellular carcinoma activity of aminopyridinol-sorafenib hybrids by Bhuwan Prasad Awasthi, Prakash Chaudhary, Diwakar Guragain, Jun-Goo Jee, Jung-Ae Kim, Byeong-Seon Jeong

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Antinociceptive potency of a fluorinated cyclopeptide Dmt-c[D-Lys-Phe-p-CF3-Phe-Asp]NH2 by Justyna Piekielna-Ciesielska, Adriano Mollica, Stefano Pieretti, Jakub Fichna, Agata Szymaszkiewicz, Marta Zielińska, Radzisław Kordek, Anna Janecka

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Bacillus lipopeptides inhibit lipase activity and promote 3T3-L1 preadipocyte differentiation by Meichun Chen, Deju Chen, Rongfeng Xiao, Xuefang Zheng, Bo Liu, Jieping Wang

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Discovery of novel isoflavone derivatives as AChE/BuChE dual-targeted inhibitors: synthesis, biological evaluation and molecular modelling by Bo Feng, Xinpeng Li, Jie Xia, Song Wu

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A reagent-free, sequence-dependent in situ peptide self-cyclization strategy under physiological condition by Nibedita Ghosh, Lal Mohan Kundu

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Synthesis and biological evaluation of new 3-substituted coumarin derivatives as selective inhibitors of human carbonic anhydrase IX and XII by Shaik Mahammad Ghouse, Kavyaraj Bahatam, Andrea Angeli, Gaurav Pawar, Krishna Kartheek Chinchilli, Venkata Madhavi Yaddanapudi, Arifuddin Mohammed, Claudiu T. Supuran, Srinivas Nanduri

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Tertiary sulphonamide derivatives as dual acting small molecules that inhibit LSD1 and suppress tubulin polymerisation against liver cancer by Lijuan Ding, Feng Wei, Nanya Wang, Yue Sun, Qiang Wang, Xia Fan, Ling Qi, Shudong Wang

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New azolyl-derivatives as multitargeting agents against breast cancer and fungal infections: synthesis, biological evaluation and docking study by Cristina Maccallini, Marialucia Gallorini, Francesca Sisto, Atilla Akdemir, Alessandra Ammazzalorso, Barbara De Filippis, Marialuigia Fantacuzzi, Letizia Giampietro, Simone Carradori, Amelia Cataldi, Rosa Amoroso

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