Search Results - "Medicinal Chemistry"

Novel piperine-carboximidamide hybrids: design, synthesis, and antiproliferative activity via a multi-targeted inhibitory pathway by Lamya H. Al-Wahaibi, Mohamed A. Mahmoud, Yaser A. Mostafa, Ali E. Raslan, Bahaa G. M. Youssif

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Discovery of novel and potent CDK8 inhibitors for the treatment of acute myeloid leukaemia by Zhuoying Chen, Quan Wang, Yao Yao Yan, Dalong Jin, Yumeng Wang, Xing Xing Zhang, Xin Hua Liu

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In vitro antimicrobial combat, molecular modelling and structure activity relationship studies of novel class of aryl-ethyne tethered coumarin analogues and some 3-aryl coumarin de... by Pavankumar Prabhala, Suraj M. Sutar, Hemantkumar M. Savanur, Shrinivas D. Joshi, Rajesh G. Kalkhambkar

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Benzo[g]quinazolin-based scaffold derivatives as dual EGFR/HER2 inhibitors by Mostafa M. Ghorab, Mansour S. Alsaid, Aiten M. Soliman, Abdullah A. Al-Mishari

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Effect of 3-subsitution of quinolinehydroxamic acids on selectivity of histone deacetylase isoforms by Samir Mehndiratta, Mei-Chuan Chen, Yuh-Hsuan Chao, Cheng-Hsin Lee, Jing-Ping Liou, Mei-Jung Lai, Hsueh-Yun Lee

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Second generation β-elemene nitric oxide derivatives with reasonable linkers: potential hybrids against malignant brain glioma by Renren Bai, Junlong Zhu, Ziqiang Bai, Qing Mao, Yingqian Zhang, Zi Hui, Xinyu Luo, Xiang-Yang Ye, Tian Xie

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A class of carbonic anhydrase I - selective activators by Erol Licsandru, Muhammet Tanc, Istvan Kocsis, Mihail Barboiu, Claudiu T. Supuran

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Blocking the FKBP12 induced dendrimeric burst in aberrant aggregation of α-synuclein by using the ElteN378 synthetic inhibitor by Gabriella Caminati, Maria Raffaella Martina, Stefano Menichetti, Piero Procacci

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A method for the efficient evaluation of substrate-based cholinesterase imaging probes for Alzheimer's disease by Sultan Darvesh, Scott Banfield, Maeve Dufour, Katrina L. Forrestall, Hillary Maillet, G. Andrew Reid, Dane Sands, Ian R. Pottie

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Drug discovery and development for neglected diseases: the DNDi model by Eric Chatelain, Jean-Robert Ioset

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Aspartic peptidase of Phialophora verrucosa as target of HIV peptidase inhibitors: blockage of its enzymatic activity and interference with fungal growth and macrophage interaction by Marcela Q. Granato, Ingrid S. Sousa, Thabatta L. S. A. Rosa, Diego S. Gonçalves, Sergio H. Seabra, Daniela S. Alviano, Maria C. V. Pessolani, André L. S. Santos, Lucimar F. Kneipp

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Synthesis and biological evaluations of oleanolic acid indole derivatives as hyaluronidase inhibitors with enhanced skin permeability by Hao He, Huifang Li, Toyosi Akanji, Shengli Niu, Zhujun Luo, Dongli Li, Navindra P. Seeram, Panpan Wu, Hang Ma

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Screening of Benzimidazole-Based Anthelmintics and Their Enantiomers as Repurposed Drug Candidates in Cancer Therapy by Rosalba Florio, Simone Carradori, Serena Veschi, Davide Brocco, Teresa Di Genni, Roberto Cirilli, Adriano Casulli, Alessandro Cama, Laura De Lellis

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3-Arylcoumarin inhibits vascular calcification by inhibiting the generation of AGEs and anti-oxidative stress by YuFei Li, Yinbo Pan, Liying Wang, Xiaojing Wang, Haiping Chu, Yan Li, Jie Sun, Yanling Mu

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Development of potent and effective SARS-CoV-2 main protease inhibitors based on maleimide analogs for the potential treatment of COVID-19 by Karol Biernacki, Olga Ciupak, Mateusz Daśko, Janusz Rachon, Damian Flis, Justyna Budka, Iwona Inkielewicz-Stępniak, Anna Czaja, Janusz Rak, Sebastian Demkowicz

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Identification of a novel SPT inhibitor WXP-003 by docking-based virtual screening and investigation of its anti-fungi effect by Xin Wang, Xin Yang, Xin Sun, Yi Qian, Mengyao Fan, Zhehao Zhang, Kaiyuan Deng, Zaixiang Lou, Zejun Pei, Jingyu Zhu

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Microwave-assisted Phospha-Michael addition reactions in the 13α-oestrone series and in vitro antiproliferative properties by Erzsébet Mernyák, Sándor Bartha, Lili Kóczán, Rebeka Jójárt, Vivien Resch, Gábor Paragi, Máté Vágvölgyi, Attila Hunyadi, Bella Bruszel, István Zupkó, Renáta Minorics

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Investigation of the enantioselectivity of acetylcholinesterase and butyrylcholinesterase upon inhibition by tacrine-iminosugar heterodimers by I. Caroline Vaaland, Óscar López, Adrián Puerta, Miguel X. Fernandes, José M. Padrón, José G. Fernández-Bolaños, Magne O. Sydnes, Emil Lindbäck

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Advances in new psychoactive substances identification: the U.R.I.To.N. Consortium by Elisabetta Bertol, Fabio Vaiano, Francesco Mari, Maria Grazia Di Milia, Silvia Bua, Claudiu T. Supuran, Fabrizio Carta

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Exploring structural and biological insights of TEAD through rational design and synthesis of niflumic acid derivatives by Yong-Sung Choi, Yoon-Jung Kim, Yeram Jeon, Jong Soon Kang, Juhee Lee, Eunmi Hong, Young-Hoon Park, Wantae Kim, Boksik Cha, Raok Jeon

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