Search Results - "Medicinal Chemistry"

Bat coronaviruses related to SARS-CoV-2: what about their 3CL proteases (MPro)? by Matteo Pavan, Davide Bassani, Mattia Sturlese, Stefano Moro

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Vitamin B6 inhibits activity of Helicobacter pylori adenylosuccinate synthetase and growth of reference and clinical, antibiotic-resistant H. pylori strains by Marta Ilona Wojtyś, Weronika Maksymiuk, Marta Narczyk, Ante Bubić, Ivana Leščić Ašler, Paweł Krzyżek, Grażyna Gościniak, Elżbieta Katarzyna Jagusztyn-Krynicka, Agnieszka Bzowska

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Design, synthesis, and evaluation of 3,7-substituted coumarin derivatives as multifunctional Alzheimer's disease agents by Sheunopa C. Mzezewa, Sylvester I. Omoruyi, Luke S. Zondagh, Sarel F. Malan, Okobi E. Ekpo, Jacques Joubert

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New horizons in drug discovery of lymphocyte-specific protein tyrosine kinase (Lck) inhibitors: a decade review (2011-2021) focussing on structure-activity relationship (SAR) and d... by Ahmed Elkamhawy, Eslam M. H. Ali, Kyeong Lee

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Structural re-positioning, in silico molecular modelling, oxidative degradation, and biological screening of linagliptin as adenosine 3 receptor (ADORA3) modulators targeting hepat... by Bassam M. Ayoub, Yasmeen M. Attia, Mahmoud S. Ahmed

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Synthesis and pharmacological evaluation of novel isoquinoline N-sulphonylhydrazones designed as ROCK inhibitors by Ramon Guerra de Oliveira, Fabiana Sélos Guerra, Cláudia dos Santos Mermelstein, Patrícia Dias Fernandes, Isadora Tairinne de Sena Bastos, Fanny Nascimento Costa, Regina Cely Rodrigues Barroso, Fabio Furlan Ferreira, Carlos Alberto Manssour Fraga

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Selected strategies to fight pathogenic bacteria by Aiva Plotniece, Arkadij Sobolev, Claudiu T. Supuran, Fabrizio Carta, Fredrik Björkling, Henrik Franzyk, Jari Yli-Kauhaluoma, Koen Augustyns, Paul Cos, Linda De Vooght, Matthias Govaerts, Juliana Aizawa, Päivi Tammela, Raivis Žalubovskis

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Pharmacophore-guided repurposing of fibrates and retinoids as GPR40 allosteric ligands with activity on insulin release by Erika Cione, Maria Cristina Caroleo, Hiroyuki Kagechika, Fabrizio Manetti

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Aryl derivatives of 3H-1,2-benzoxathiepine 2,2-dioxide as carbonic anhydrase inhibitors by Aleksandrs Pustenko, Alessio Nocentini, Anastasija Balašova, Ahmed Alafeefy, Mikhail Krasavin, Raivis Žalubovskis, Claudiu T. Supuran

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The importance of including the C-terminal domain of PTP1B1-400 to identify potential antidiabetic inhibitors by Andrea Coronell-Tovar, Francisco Cortés-Benítez, Martin González-Andrade

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Synthesis and in vitro antiproliferative and antibacterial activity of new thiazolidine-2,4-dione derivatives by Nazar Trotsko, Agata Przekora, Justyna Zalewska, Grażyna Ginalska, Agata Paneth, Monika Wujec

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Design, synthesis, and biological evaluation of triazole-pyrimidine-methylbenzonitrile derivatives as dual A2A/A2B adenosine receptor antagonists by Zhi Li, Lijuan Kou, Xinzhen Fu, Zeping Xie, Maolei Xu, Lin Guo, Tiantian Lin, Shizhou Gong, Shumin Zhang, Ming Liu

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Synthesis and antitumor activity of litseaone B analogues as tubulin polymerisation inhibitors by Wei Yang, Huining Peng, Yong Huang, Zhiyun Peng, Guangcheng Wang

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Identification of histone deacetylase inhibitors with (arylidene)aminoxy scaffold active in uveal melanoma cell lines by Susanna Nencetti, Doretta Cuffaro, Elisa Nuti, Lidia Ciccone, Armando Rossello, Marina Fabbi, Flavio Ballante, Gabriella Ortore, Grazia Carbotti, Francesco Campelli, Irene Banti, Rosaria Gangemi, Garland R. Marshall, Elisabetta Orlandini

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Exploring the medicinal significance of l-Arginine mediated nitric oxide in preventing health disorders by Mega Obukohwo Oyovwi, Adedeji David Atere

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The classification and therapeutic applications of molecular motors by Mingyuan Li, Yuan Li, Lin Jia, Shiqin Li, Meng Li, Guang Yang, Nan Liu, Hongmeng Ren, Mingqi Mou, Aiping Zheng, Hua Sun

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Crystal structure of ricin toxin A chain complexed with a highly potent pterin-based small-molecular inhibitor by Masaru Goto, Natsumi Sakamoto, Shoko Higashi, Rena Kawata, Kazuki Nagatsu, Ryota Saito

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New pentadienone oxime ester derivatives: synthesis and anti-inflammatory activity by Qin Li, Juping Zhang, Liu Zeng Chen, Jie Quan Wang, Hai Ping Zhou, Wen Jian Tang, Wei Xue, Xin Hua Liu

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Nano-bio interfaces effect of two-dimensional nanomaterials and their applications in cancer immunotherapy by Zhongmin Tang, Yufen Xiao, Na Kong, Chuang Liu, Wei Chen, Xiangang Huang, Daiyun Xu, Jiang Ouyang, Chan Feng, Cong Wang, Junqing Wang, Han Zhang, Wei Tao

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Application of Ligand- and Structure-Based Prediction Models for the Design of Alkylhydrazide-Based HDAC3 Inhibitors as Novel Anti-Cancer Compounds by Emre F. Bülbül, Dina Robaa, Ping Sun, Fereshteh Mahmoudi, Jelena Melesina, Matthes Zessin, Mike Schutkowski, Wolfgang Sippl

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