Search Results - "Medicinal Chemistry"

The three-tails approach as a new strategy to improve selectivity of action of sulphonamide inhibitors against tumour-associated carbonic anhydrase IX and XII by Alessandro Bonardi, Silvia Bua, Jacob Combs, Carrie Lomelino, Jacob Andring, Sameh Mohamed Osman, Alessandra Toti, Lorenzo Di Cesare Mannelli, Paola Gratteri, Carla Ghelardini, Robert McKenna, Alessio Nocentini, Claudiu T. Supuran

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(E)-7-Ethylidene-lithocholic Acid (7-ELCA) Is a Potent Dual Farnesoid X Receptor (FXR) Antagonist and GPBAR1 Agonist Inhibiting FXR-Induced Gene Expression in Hepatocytes and Stimu... by Alzbeta Stefela, Miroslav Kaspar, Miroslav Kaspar, Martin Drastik, Thales Kronenberger, Thales Kronenberger, Stanislav Micuda, Martin Dracinsky, Blanka Klepetarova, Eva Kudova, Petr Pavek

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Natural acetylcholinesterase inhibitors: A multi-targeted therapeutic potential in Alzheimer's disease by Kumar Gajendra, G.K. Pratap, D.V. Poornima, Manjula Shantaram, G. Ranjita

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Synthesis and biological evaluation of flavonoid-based IP6K2 inhibitors by Myunghwan Ahn, Seung Eun Park, Jiyeon Choi, Jiahn Choi, Doyoung Choi, Dongju An, Hayoung Jeon, Soowhan Oh, Kiho Lee, Jaehoon Kim, Jaebong Jang, Seyun Kim, Youngjoo Byun

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Development of iminosugar-based glycosidase inhibitors as drug candidates for SARS-CoV-2 virus via molecular modelling and in vitro studies by Zorana Ferjancic, Filip Bihelovic, Bojan Vulovic, Radomir Matovic, Milena Trmcic, Aleksandar Jankovic, Milos Pavlovic, Filip Djurkovic, Radivoje Prodanovic, Aleksandra Djurdjevic Djelmas, Nevena Kalicanin, Mario Zlatovic, Dusan Sladic, Thomas Vallet, Marco Vignuzzi, Radomir N. Saicic

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Multitarget drugs as potential therapeutic agents for alzheimer's disease. A new family of 5-substituted indazole derivatives as cholinergic and BACE1 inhibitors by Pedro González-Naranjo, Concepción Pérez, Marina González-Sánchez, Adrián Gironda-Martínez, Eugenia Ulzurrun, Fernando Bartolomé, Marcos Rubio-Fernández, Angeles Martin-Requero, Nuria E. Campillo, Juan A. Páez

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Synthesis, anticancer activities and experimental-theoretical DNA interaction studies of 2-amino-4-phenyl-4H-benzo[h]chromene-3-carbonitrile by Taniris Cafiero Braga, Marina Magalhães Silva, Eduarda O.O. Nascimento, Edjan Carlos Dantas da Silva, Yuri de Freitas Rego, Mullicka Mandal, Zaqueu Alves de Souza, Ana Lúcia Tasca Góis Ruiz, João Ernesto de Carvalho, Felipe Terra Martins, Isis Martins Figueiredo, Thiago Mendonça de Aquino, Cleiton Moreira da Silva, Bhagirath Mandal, Goutam Brahmachari, Josué Carinhanha Caldas Santos, Ângelo de Fátima

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Prognostic value of CAIX expression in oral squamous cell carcinoma: a systematic review and meta-analysis by Alejandro I. Lorenzo-Pouso, Mercedes Gallas-Torreira, Mario Pérez-Sayáns, Cintia M. Chamorro-Petronacci, Oscar Alvarez-Calderon, Bahi Takkouche, Claudiu T. Supuran, Abel García-García

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New cyclopentaquinoline and 3,5-dichlorobenzoic acid hybrids with neuroprotection against oxidative stress for the treatment of Alzheimer's disease by Kamila Czarnecka, Małgorzata Girek, Paweł Kręcisz, Robert Skibiński, Kamil Łątka, Jakub Jończyk, Marek Bajda, Piotr Szymczyk, Grzegorz Galita, Jacek Kabziński, Ireneusz Majsterek, Alba Espargaró, Raimon Sabate, Paweł Szymański

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Synthesis and bioactivity of several new hetaryl sulfonamides by Parham Taslimi, Afsun Sujayev, Sevgi Mamedova, Pınar Kalın, İlhami Gulçin, Nastaran Sadeghian, Sukru Beydemir, O. Irfan Kufrevioglu, Saleh H. Alwasel, Vagif Farzaliyev, Sabir Mamedov

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Dual and selective inhibitors of pteridine reductase 1 (PTR1) and dihydrofolate reductase-thymidylate synthase (DHFR-TS) from Leishmania chagasi by Bárbara Velame Ferreira Teixeira, André Lacerda Braga Teles, Suellen Gonçalves da Silva, Camila Carane Bitencourt Brito, Humberto Fonseca de Freitas, Acássia Benjamim Leal Pires, Thamires Quadros Froes, Marcelo Santos Castilho

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Towards safer anti-inflammatory therapy: synthesis of new thymol-pyrazole hybrids as dual COX-2/5-LOX inhibitors by Mostafa M. M. El-Miligy, Ahmed K. Al-Kubeisi, Mohamed G. Bekhit, Saad R. El-Zemity, Rasha A. Nassra, Aly A. Hazzaa

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Development of 3-methyl/3-(morpholinomethyl)benzofuran derivatives as novel antitumor agents towards non-small cell lung cancer cells by Mohammad M. Al-Sanea, Ghada H. Al-Ansary, Zainab M. Elsayed, Raed M. Maklad, Eslam B. Elkaeed, Mohamed A. Abdelgawad, Syed Nasir Abbas Bukhari, Marwa M. Abdel-Aziz, Howayda Suliman, Wagdy M. Eldehna

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Photoredox-catalyzed reaction as a powerful tool for rapid natural product Gem -dimethylation modification: discovery of potent anti-cancer agents with improved druggability by Chao Zhang, Yugang Song, Xiuyun Sun, Qianlong Liu, Zhen Li, Shenyi Yin, Jianzhong Jeff Xi, Xin Zhai, Yu Rao

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Sesquiterpene lactone derivatives of KSL-B targeting Arf1-Big1Sec7 interaction by Sergio Ortiz, François Peurois, Euzébio Guimarães Barbosa, Mohamed Selkti, Pascale Lemoine, Jacqueline Cherfils, Raphaël Grougnet, Sabrina Boutefnouchet

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Use of an immobilised thermostable α-CA (SspCA) for enhancing the metabolic efficiency of the freshwater green microalga Chlorella sorokiniana by Giovanna Salbitani, Sonia Del Prete, Francesco Bolinesi, Olga Mangoni, Viviana De Luca, Vincenzo Carginale, William A. Donald, Claudiu T. Supuran, Simona Carfagna, Clemente Capasso

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Targeting breast cancer using phytoconstituents: Nanomedicine-based drug delivery by Neelam Laxman Dashputre, Jayesh D. Kadam, Umesh D. Laddha, Surabhi B. Patil, Pavan B. Udavant, Smita P. Kakad

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Design, synthesis and biological evaluation of tricyclic pyrazolo[1,5-c][1,3]benzoxazin-5(5H)-one scaffolds as selective BuChE inhibitors by Guo-Liang Qiu, Shao-Sheng He, Shi-Chao Chen, Bo Li, Hui-Hui Wu, Jing Zhang, Wen-Jian Tang

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Novel Sunifiram-carbamate hybrids as potential dual acetylcholinesterase inhibitor and NMDAR co-agonist: simulation-guided analogue design and pharmacological screening by Khalid A. Agha, Nader E. Abo-Dya, Abdul Rashid Issahaku, Clement Agoni, Mahmoud E. S. Soliman, Eatedal H. Abdel-Aal, Zakaria K. Abdel-Samii, Tarek S. Ibrahim

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Pyridinium-2-carbaldoximes with quinolinium carboxamide moiety are simultaneous reactivators of acetylcholinesterase and butyrylcholinesterase inhibited by nerve agent surrogates by Hyun Myung Lee, Rudolf Andrys, Jakub Jonczyk, Kyuneun Kim, Avinash G. Vishakantegowda, David Malinak, Adam Skarka, Monika Schmidt, Michaela Vaskova, Kamil Latka, Marek Bajda, Young-Sik Jung, Barbara Malawska, Kamil Musilek

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