Search Results - "Medicinal Chemistry"

Dual inhibition of EGFR and IL-6-STAT3 signalling by miR-146b: a potential targeted therapy for epithelial ovarian cancer by Meina Yan, Mutian Han, Xinxin Yang, Rong Shen, Hui Wang, Lubin Zhang, Sheng Xia, Peifang Yang, Guanghua Zhai, Qixiang Shao

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Progression in nano-botanical oral hygiene solutions: The Dawn of biomimetic nanomaterials by Aqsa Arif, Muhammad Sharif Khar, Nariman Shahid, Waqar Aman, Joham Javed, Amina Rubab, Mashal Nayab, khadija mastoor, Rabia Arshad, Abbas Rahdar, Sonia Fathi-karkan, Zelal Kharaba, Sadanand Pandey

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Disulfiram moderately restores impaired hepatic redox status of rats subchronically exposed to cadmium by Aida Begic, Ana Djuric, Milica Ninkovic, Ivana Stevanovic, Dragan Djurdjevic, Milos Pavlovic, Katarina Jelic, Ana Pantelic, Goran Zebic, Bratislav Dejanovic, Ivan Stanojevic, Danilo Vojvodic, Petar Milosavljevic, Mirjana Djukic, Luciano Saso

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2,6-Bis(2-Benzimidazolyl)Pyridine (BBP) Is a Potent and Selective Inhibitor of Small Conductance Calcium-Activated Potassium (SK) Channels by Rafel Simó-Vicens, Rafel Simó-Vicens, Sofia H. Bomholtz, Sofia H. Bomholtz, Ulrik S. Sørensen, Bo H. Bentzen, Bo H. Bentzen

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Pharmacophore-based design and discovery of (−)-meptazinol carbamates as dual modulators of cholinesterase and amyloidogenesis by Qiong Xie, Zhaoxi Zheng, Biyun Shao, Wei Fu, Zheng Xia, Wei Li, Jian Sun, Wei Zheng, Weiwei Zhang, Wei Sheng, Qihong Zhang, Hongzhuan Chen, Hao Wang, Zhuibai Qiu

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New imidazole-2-thiones linked to acenaphythylenone as dual DNA intercalators and topoisomerase II inhibitors: structural optimization, docking, and apoptosis studies by Asmaa H. Mohamed, Mohammed B. Alshammari, Ashraf A. Aly, Kamal U. Sadek, Akil Ahmad, Eman A. Aziz, Amira F. El-Yazbi, Eman J. El-Agroudy, Marwa E. Abdelaziz

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Screening the pandemic response box identified benzimidazole carbamates, Olorofim and ravuconazole as promising drug candidates for the treatment of eumycetoma. by Wilson Lim, Bertrand Nyuykonge, Kimberly Eadie, Mickey Konings, Juli Smeets, Ahmed Fahal, Alexandro Bonifaz, Matthew Todd, Benjamin Perry, Kirandeep Samby, Jeremy Burrows, Annelies Verbon, Wendy van de Sande

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A novel series of putative Brugia malayi histone demethylase inhibitors as potential anti-filarial drugs. by Tamara Kreiss, Tyler Eck, Brittany Hart, Sreedhar Tummalapalli, David Rotella, John Siekierka

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Investigating novel thiazolyl-indazole derivatives as scaffolds for SARS-CoV-2 MPro inhibitors by Justin Airas, Catherine A. Bayas, Abdellah N'Ait Ousidi, Moulay Youssef Ait Itto, Aziz Auhmani, Mohamed Loubidi, M'hamed Esseffar, Julie A. Pollock, Carol A. Parish

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Discovery of N-(1-(3-fluorobenzoyl)-1H-indol-5-yl)pyrazine-2-carboxamide: a novel, selective, and competitive indole-based lead inhibitor for human monoamine oxidase B by Ahmed Elkamhawy, Sora Paik, Hyeon Jeong Kim, Jong-Hyun Park, Ashwini M. Londhe, Kyeong Lee, Ae Nim Pae, Ki Duk Park, Eun Joo Roh

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2,4-Diaminothieno[3,2-d]pyrimidines, a new class of anthelmintic with activity against adult and egg stages of whipworm. by Frederick A Partridge, Ruth Forman, Nicky J Willis, Carole J R Bataille, Emma A Murphy, Anwen E Brown, Narinder Heyer-Chauhan, Bruno Marinič, Daniel J C Sowood, Graham M Wynne, Kathryn J Else, Angela J Russell, David B Sattelle

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Synthesis of Novel Quinazolinone Analogues for Quorum Sensing Inhibition by Sahil Shandil, Tsz Tin Yu, Shekh Sabir, David StC. Black, Naresh Kumar

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o-Vanillin binds covalently to MAL/TIRAP Lys-210 but independently inhibits TLR2 by Md. Habibur Rahaman, Sara J. Thygesen, Michael J. Maxwell, Hyoyoung Kim, Prerna Mudai, Jeffrey D. Nanson, Xinying Jia, Parimala R. Vajjhala, Andrew Hedger, Irina Vetter, Thomas Haselhorst, Avril A. B. Robertson, Brian Dymock, Thomas Ve, Mehdi Mobli, Katryn J. Stacey, Bostjan Kobe

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Impact of organotin compounds on the growth of epidermoid Lewis carcinoma by Margarita A. Dodokhova, Andrei V. Safronenko, Inga M. Kotieva, Margarita S. Alkhuseyn-Kulyaginova, Dmitry B. Shpakovsky, Elena R. Milaeva

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Antimicrobial evaluation and QSAR studies of 3,6-disubstituted-11H-benzo[5,6][1,4]thiazino[3,4-a]isoindol-11-ones by Satbir Mor, Suchita Sindhu, Mohini Khatri, Ravinder Punia, Hardeep Sandhu, Jayant Sindhu, Komal Jakhar

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Design, synthesis, molecular modeling and biological evaluation of novel Benzoxazole-Benzamide conjugates via a 2-Thioacetamido linker as potential anti-proliferative agents, VEGFR... by Ibrahim H. Eissa, Radwan El-Haggar, Mohammed A. Dahab, Marwa F. Ahmed, Hazem A. Mahdy, Reem I. Alsantali, Alaa Elwan, Nicolas Masurier, Samar S. Fatahala

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Multi-stage structure-based virtual screening approach towards identification of potential SARS-CoV-2 NSP13 helicase inhibitors by Mahmoud A. El Hassab, Wagdy M. Eldehna, Sara T. Al-Rashood, Amal Alharbi, Razan O. Eskandrani, Hamad M. Alkahtani, Eslam B. Elkaeed, Sahar M. Abou-Seri

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Targeting p21-activated kinase 4 (PAK4) with pyrazolo[3,4-d]pyrimidine derivative SPA7012 attenuates hepatic ischaemia-reperfusion injury in mice by Yuancheng Mao, Eun Lee, Xiaohui Yang, Eun Ju Bae, Raok Jeon, Byung-Hyun Park

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Synthesis, anti-bacterial and anti-protozoal activities of amidinobenzimidazole derivatives and their interactions with DNA and RNA by Andrea Bistrović, Luka Krstulović, Ivana Stolić, Domagoj Drenjančević, Jasminka Talapko, Martin C. Taylor, John M. Kelly, Miroslav Bajić, Silvana Raić-Malić

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Antiproliferative activity and p53 upregulation effects of chalcones on human breast cancer cells by Mariana Bastos dos Santos, Daiane Bertholin Anselmo, Jéssica Gisleine de Oliveira, Bruna V. Jardim-Perassi, Diego Alves Monteiro, Gabriel Silva, Eleni Gomes, Ana Lucia Fachin, Mozart Marins, Débora Aparecida Pires de Campos Zuccari, Luis Octavio Regasini

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