Search Results - "Medicinal Chemistry"

Design and synthesis of some new benzoylthioureido benzenesulfonamide derivatives and their analogues as carbonic anhydrase inhibitors by Khulood H. Oudah, Walaa R. Mahmoud, Fadi M. Awadallah, Azza T. Taher, Safinaz E.-S Abbas, Heba Abdelrasheed Allam, Daniela Vullo, Claudiu T. Supuran

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Optimization of biguanide derivatives as selective antitumor agents blocking adaptive stress responses in the tumor microenvironment by Narise K, Okuda K, Enomoto Y, Hirayama T, Nagasawa H

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Phenotypic screening of low molecular weight compounds is rich ground for repurposed, on-target drugs by Christopher A. Lipinski, Andrew G. Reaume

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Comparative analyses of downstream signal transduction targets modulated after activation of the AT1 receptor by two β-arrestin biased agonists by Geisa A Santos, Diego A Duarte, Lucas T Parreiras-, Felipe R Teixeira, Felipe R Teixeira, Rafael M Silva-Rocha, Eduardo B Oliveira, Michel eBouvier, Claudio M Costa-Neto, Claudio M Costa-Neto

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New 1,2,4-oxadiazole derivatives with positive mGlu4 receptor modulation activity and antipsychotic-like properties by Anna Stankiewicz, Katarzyna Kaczorowska, Ryszard Bugno, Aneta Kozioł, Maria H. Paluchowska, Grzegorz Burnat, Barbara Chruścicka, Paulina Chorobik, Piotr Brański, Joanna M. Wierońska, Beata Duszyńska, Andrzej Pilc, Andrzej J. Bojarski

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A New Guanidine-Core Small-Molecule Compound as a Potential Antimicrobial Agent against Resistant Bacterial Strains by Noelia Morata-Moreno, Ramón Pérez-Tanoira, Almudena del Campo-Balguerias, Fernando Carrillo-Hermosilla, Marcos Hernando-Gozalo, Carlos Rescalvo-Casas, Ana V. Ocana, Pedro Segui, Carlos Alonso-Moreno, Francisco C. Pérez-Martínez, Milagros Molina-Alarcón

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Design, Synthesis, Characterization and in vivo Antidiabetic Activity Evaluation of Some Chalcone Derivatives by Welday Kahssay S, Hailu GS, Taye Desta K

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Design, synthesis, docking, ADMET studies, and anticancer evaluation of new 3-methylquinoxaline derivatives as VEGFR-2 inhibitors and apoptosis inducers by Mohammed M. Alanazi, Ibrahim H. Eissa, Nawaf A. Alsaif, Ahmad J. Obaidullah, Wael A. Alanazi, Abdullah F. Alasmari, Hussam Albassam, Hazem Elkady, Alaa Elwan

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Design, synthesis, apoptotic, and antiproliferative effects of 5-chloro-3- (2-methoxyvinyl)-indole-2-carboxamides and pyrido[3,4-b]indol-1-ones as potent EGFRWT/EGFRT790M inhibitor... by Lamya H. Al-Wahaibi, Anber F. Mohammed, Fatema El-Zahraa S. Abdel Rahman, Mostafa H. Abdelrahman, Xuyuan Gu, Laurent Trembleau, Bahaa G. M. Youssif

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Parasitological profiling shows 4(1H)-quinolone derivatives as new lead candidates for malaria by Juliana O. de Souza, Suzete M. Almeida, Guilherme E. Souza, Camila L. Zanini, Everton M. da Silva, Juliana Calit, Daniel Y. Bargieri, Kangsa Amporndanai, Svetlana Antonyuk, S. Samar Hasnain, Fabio C. Cruz, Dhelio B. Pereira, Glaucius Oliva, Arlene G. Corrêa, Anna C.C. Aguiar, Rafael V.C. Guido

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Decoding the anti-Leishmania braziliensis activity of 1,10-phenanthroline-5,6-dione and its silver- and copper-based complexes: In vitro and in vivo approaches by André L.S. Santos, Ana Karina C. Lima, Simone S.C. Oliveira, Rosiane F. dos Santos, Michael Devereux, Malachy McCann, Marta H. Branquinha, Patrícia M.L. Dutra

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Novel pyrrolizines bearing 3,4,5-trimethoxyphenyl moiety: design, synthesis, molecular docking, and biological evaluation as potential multi-target cytotoxic agents by Ahmed M. Shawky, Nashwa A. Ibrahim, Ashraf N. Abdalla, Mohammed A. S. Abourehab, Ahmed M. Gouda

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2-Amino-1,3,4-thiadiazole as a potential scaffold for promising antimicrobial agents by Serban G, Stanasel O, Serban E, Bota S

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Plant Metabolites as SARS-CoV-2 Inhibitors Candidates: In Silico and In Vitro Studies by Alberto Jorge Oliveira Lopes, Gustavo Pereira Calado, Yuri Nascimento Fróes, Sandra Alves de Araújo, Lucas Martins França, Antonio Marcus de Andrade Paes, Sebastião Vieira de Morais, Cláudia Quintino da Rocha, Cleydlenne Costa Vasconcelos

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Snakebite drug discovery: high-throughput screening to identify novel snake venom metalloproteinase toxin inhibitors by Rachel H. Clare, Rachel H. Clare, Charlotte A. Dawson, Charlotte A. Dawson, Adam Westhorpe, Adam Westhorpe, Laura-Oana Albulescu, Laura-Oana Albulescu, Christopher M. Woodley, Nada Mosallam, Daniel J. W. Chong, Jeroen Kool, Neil G. Berry, Paul M. O'Neill, Nicholas R. Casewell, Nicholas R. Casewell

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Building a ML-based QSAR model for predicting the bioactivity of therapeutically active drug class with imidazole scaffold by Komal Singh, Irina Ghosh, Venkatesan Jayaprakash, Sudeepan Jayapalan

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Kolaviron ameliorates chronic colitis induced by prolonged oral administration of Dextran Sulphate Sodium in Balb/c mice by Babajide O. Ajayi, Isaac A. Adedara, Onyediaka C. Emeka, Praise B. Awoyinka, Opeoluwa O. Beckley, Ademoyeje A. Adeleye, Ebenezer O. Farombi

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Design, synthesis, molecular modelling and antitumor evaluation of S-glucosylated rhodanines through topo II inhibition and DNA intercalation by Ahmed I. Khodair, Fatimah M. Alzahrani, Mohamed K. Awad, Siham A. Al-Issa, Ghaferah H. Al-Hazmi, Mohamed S. Nafie

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Synthesis, antitumour activities and molecular docking of thiocarboxylic acid ester-based NSAID scaffolds: COX-2 inhibition and mechanistic studies by Adel S. El-Azab, Alaa A.-M, Laila A. Abou-Zeid, Walaa M. El-Husseiny, Ahmad M. El_Morsy, Manal A. El-Gendy, Magda A.-

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Molecular docking and synthesis of N-alkyl-isatin-3-imino aromatic amine derivatives and their antileishmanial and cytotoxic activities by Farshid Hassanzadeh, Seyed Hossein Hejazi, Elham Jafari, Atefeh Mohammadi fard, Hojjat Sadeghi-aliabadi

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