Search Results - "Medicinal Chemistry"

Discovery of novel, orally bioavailable, antileishmanial compounds using phenotypic screening. by Diana Ortiz, W Armand Guiguemde, Jared T Hammill, Angela K Carrillo, Yizhe Chen, Michele Connelly, Kayla Stalheim, Carolyn Elya, Alex Johnson, Jaeki Min, Anang Shelat, David C Smithson, Lei Yang, Fangyi Zhu, R Kiplin Guy, Scott M Landfear

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Novel N-substituted aminobenzamide scaffold derivatives targeting the dipeptidyl peptidase-IV enzyme by Al-Balas QA, Sowaileh MF, Hassan MA, Qandil AM, Alzoubi KH, Mhaidat NM, Almaaytah AM, Khabour OF

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In silico and in vivo characterization of cabralealactone, solasodin and salvadorin in a rat model: potential anti-inflammatory agents by Malik A, Arooj M, Butt TT, Zahid S, Zahid F, Jafar TH, Waquar S, Gan SH, Ahmad S, Mirza MU

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Correlation between lamivudine plasma concentrations and patient self-reported adherence to antiretroviral treatment in experienced HIV patients by Minzi OM, Mugoyela V, Gustafsson LL

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Single Nucleotide Polymorphism in the 3’ Untranslated Region of PRKAA2 on Cardiometabolic Parameters in Type 2 Diabetes Mellitus Patients Who Received Metformin by Virginia DM, Patramurti C, Fenty, Setiawan CH, Julianus J, Hendra P, Susanto NAP

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Synthesis of 2-(6-substituted quinolin-4-yl)-1-(4-aryl-1H-1,2,3-triazol-1-yl) propan-2-ol as potential antifungal and antitubercular agents by Abhijit Shinde, Prashant P. Thakare, Yogesh Nandurkar, Manish Bhoye, Abhijit Chavan, Pravin C. Mhaske

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Identification of Drug Combination Therapies for SARS-CoV-2: A Molecular Dynamics Simulations Approach by Abdel-Halim H, Hajar M, Hasouneh L, Abdelmalek SMA

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A Triple High Throughput Screening for Extracellular Vesicle Inducing Agents With Immunostimulatory Activity by Nikunj M. Shukla, Fumi Sato-Kaneko, Shiyin Yao, Minya Pu, Michael Chan, Fitzgerald S. Lao, Yukiya Sako, Tetsuya Saito, Tetsuya Saito, Karen Messer, Tomoko Hayashi, Howard B. Cottam, Maripat Corr, Dennis A. Carson

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Design, Synthesis, and Spectroscopic Studies of Some New α-Aminophosphonate Analogues Derived from 4-Hydroxybenzaldehyde with Special Reference to Anticancer Activity by Ali OM, Alotaibi MT, Zaki YH, Amer HH

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The diterpenoid 7-keto-sempervirol, derived from Lycium chinense, displays anthelmintic activity against both Schistosoma mansoni and Fasciola hepatica. by Jennifer Edwards, Martha Brown, Emily Peak, Barbara Bartholomew, Robert J Nash, Karl F Hoffmann

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Amantadine variant - aryl conjugates that inhibit multiple M2 mutant - amantadine resistant influenza a viruses by Christina Tzitzoglaki, Anja Hoffmann, Andreea L. Turcu, Patrick Schmerer, Chunlong Ma, George Laros, Christos Liolios, Brea José, Jun Wang, Santiago Vázquez, Michaela Schmidtke, Antonios Kolocouris

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SCYX-7158, an orally-active benzoxaborole for the treatment of stage 2 human African trypanosomiasis. by Robert T Jacobs, Bakela Nare, Stephen A Wring, Matthew D Orr, Daitao Chen, Jessica M Sligar, Matthew X Jenks, Robert A Noe, Tana S Bowling, Luke T Mercer, Cindy Rewerts, Eric Gaukel, Jennifer Owens, Robin Parham, Ryan Randolph, Beth Beaudet, Cyrus J Bacchi, Nigel Yarlett, Jacob J Plattner, Yvonne Freund, Charles Ding, Tsutomu Akama, Y-K Zhang, Reto Brun, Marcel Kaiser, Ivan Scandale, Robert Don

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Drug-likeness approach of 2-aminopyrimidines as histamine H3 receptor ligands by Sadek B, Schreeb A, Schwed JS, Weizel L, Stark H

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Compounds Derived from the Bhutanese Daisy, Ajania nubigena, Demonstrate Dual Anthelmintic Activity against Schistosoma mansoni and Trichuris muris. by Phurpa Wangchuk, Mark S Pearson, Paul R Giacomin, Luke Becker, Javier Sotillo, Darren Pickering, Michael J Smout, Alex Loukas

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4-Aryl-N-phenylpyrimidin-2-amines targeting EGFR-tyrosine kinase attenuated EGFR-expressing cell lines by Lueacha Tabtimmai, Prapasri Supakun, Borvornvat Toviwek, Nattanan Jiwacharoenchai, Duangnapa Kiriwan, Thitinan Aiebchun, M. Paul Gleeson, Kiattawee Choowongkomon

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Design, synthesis, and pharmacological evaluation of 2-amino-5-nitrothiazole derived semicarbazones as dual inhibitors of monoamine oxidase and cholinesterase: effect of the size o... by Rati K. P. Tripathi, Vishnu M. Sasi, Sukesh K. Gupta, Sairam Krishnamurthy, Senthil R. Ayyannan

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Discovery of new 3-methylquinoxalines as potential anti-cancer agents and apoptosis inducers targeting VEGFR-2: design, synthesis, and in silico studies by Mohammed M. Alanazi, Alaa Elwan, Nawaf A. Alsaif, Ahmad J. Obaidullah, Hamad M. Alkahtani, Abdulrahman A. Al-Mehizia, Sultan M. Alsubaie, Mohammed S. Taghour, Ibrahim H. Eissa

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Ligand-based design and synthesis of N'-Benzylidene-3,4-dimethoxybenzohydrazide derivatives as potential antimicrobial agents; evaluation by in vitro, in vivo, and in silico approa... by Rogy R. Ezz Eldin, Marwa A. Saleh, Mohammad Hayal Alotaibi, Reem K. Alsuair, Yahya A. Alzahrani, Feras A. Alshehri, Amany F. Mohamed, Shaimaa M. Hafez, Azza Ali Althoqapy, Seham K. Khirala, Mona M. Amin, Yousuf A. F, Azza H. AbdElwahab, Mohamed S. Alesawy, Ayman Abo Elmaaty, Ahmed A. Al-Karmalawy

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Novel oxindole/benzofuran hybrids as potential dual CDK2/GSK-3β inhibitors targeting breast cancer: design, synthesis, biological evaluation, and in silico studies by Wagdy M. Eldehna, Sara T. Al-Rashood, Tarfah Al-Warhi, Razan O. Eskandrani, Amal Alharbi, Ahmed M. El Kerdawy

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Hesperetin-5,7,3ʹ-O-Trimethylether Dually Inhibits Phosphodiesterase 3/4 and Methacholine-Induced Airway Hyperresponsiveness in Sensitized and Challenged Mice by Shih CH, Wang WH, Chen CM, Ko WC

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