Zoekresultaten - "Preclinical development"

Introduction to small molecule drug discovery and preclinical development door Michelle W. Y. Southey, Michael Brunavs

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A minimal PBPK model to accelerate preclinical development of drugs against tuberculosis door Federico Reali, Anna Fochesato, Anna Fochesato, Chanchala Kaddi, Roberto Visintainer, Shayne Watson, Micha Levi, Véronique Dartois, Karim Azer, Luca Marchetti, Luca Marchetti

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PBPK-PD modeling for the preclinical development and clinical translation of tau antibodies for Alzheimer's disease door Peter Bloomingdale, Daniela Bumbaca-Yadav, Jonathan Sugam, Steve Grauer, Brad Smith, Svetlana Antonenko, Michael Judo, Glareh Azadi, Ka Lai Yee

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Therapeutic Potential of Controlled Delivery Systems in Asthma: Preclinical Development of Flavonoid-Based Treatments door Sergio M. Borghi, Tiago H. Zaninelli, Jéssica B. Carra, Olivia K. Heintz, Marcela M. Baracat, Sandra R. Georgetti, Fabiana T. M. C. Vicentini, Waldiceu A. Verri, Rubia Casagrande

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Development of a Minimalistic Physiologically Based Pharmacokinetic (mPBPK) Model for the Preclinical Development of Spectinamide Antibiotics door Keyur R. Parmar, Pradeep B. Lukka, Santosh Wagh, Zaid H. Temrikar, Jiuyu Liu, Richard E. Lee, Miriam Braunstein, Anthony J. Hickey, Gregory T. Robertson, Mercedes Gonzalez-Juarrero, Andrea Edginton, Bernd Meibohm

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Dengue, West Nile, and Zika Viruses: Potential Novel Antiviral Biologics Drugs Currently at Discovery and Preclinical Development Stages door Ivo C. Martins, Rafaela C. Ricardo, Nuno C. Santos

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Preclinical Development of a Subcutaneous ALAS1 RNAi Therapeutic for Treatment of Hepatic Porphyrias Using Circulating RNA Quantification door Amy Chan, Abigail Liebow, Makiko Yasuda, Lin Gan, Tim Racie, Martin Maier, Satya Kuchimanchi, Don Foster, Stuart Milstein, Klaus Charisse, Alfica Sehgal, Muthiah Manoharan, Rachel Meyers, Kevin Fitzgerald, Amy Simon, Robert J Desnick, William Querbes

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Discovery and Preclinical Development of Orally Active Small Molecules that Exhibit Highly Selective Follicle Stimulating Hormone Receptor Agonism door Selva Nataraja, Henry Yu, Joie Guner, Stephen Palmer, Stephen Palmer

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Erratum: Discovery and Preclinical Development of Orally Active Small Molecules That Exhibit Highly Selective Follicle Stimulating Hormone Receptor Agonism door Frontiers Production Office

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Pharmacokinetic Modeling to Guide Preclinical Development of an Islatravir-Eluting Reservoir-Style Biodegradable Implant for Long-Acting HIV PrEP door Talisa S. Kinsale, Mackenzie L. Cottrell, Linying Li, Rhonda Brand, Greg Gatto, Ellen Luecke, Chasity Norton, Archana Krovi, Julie B. Dumond, Gauri Rao, Shekhar Yeshwante, Brian Van Horne, Ariane Van Der Straten, Angela D. M. Kashuba, Leah M. Johnson

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New Preclinical Development of a c-Met Inhibitor and Its Combined Anti-Tumor Effect in c-Met-Amplified NSCLC door Nam Ah Kim, Sungyoul Hong, Ki Hyun Kim, Du Hyung Choi, Joo Seok Kim, Kyung Eui Park, Jun Young Choi, Young Kee Shin, Seong Hoon Jeong

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Preclinical Development of SHR-1819, a Potent Humanized IL-4Rα Antibody for Treating Type 2 Inflammatory Diseases door Zhao G, Wang Z, Zhang J, Lin Y, Zhou T, Liu K, Yang C, Liao C

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Izokibep: Preclinical development and first-in-human study of a novel IL-17A neutralizing Affibody molecule in patients with plaque psoriasis door Susanne Klint, Joachim Feldwisch, Lindvi Gudmundsdotter, Karin Dillner Bergstedt, Elin Gunneriusson, Ingmarie Höidén Guthenberg, Anders Wennborg, Andrew C. Nyborg, Amol P. Kamboj, Paul M. Peloso, David Bejker, Fredrik Y. Frejd

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Process validation and preclinical development of a new PET cerebral blood flow tracer [11C]MMP for initial clinical trials door Jun Toyohara, Tetsuro Tago, Muneyuki Sakata

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Preclinical development of a bispecific HIV x CD3 DART molecule that redirects T cells to kill HIV envelope (env)-expressing cells door J.L. Nordstrom, C. Nixon, J. Pickeral, C.h.-Y. Kao Lam, L. Liu, H. Li, S. Sharma, S. Gorlatov, F. Chen, K. Sampathkumar, G.D. Tomaras, S.M. Alam, P. Tsai, T. Morgan, P.T. Ho, B.F. Haynes, G. Ferrari, J.A. Sung, D.M. Margolis, J. Victor Garcia, S. Koenig

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Preclinical Development of Autologous Hematopoietic Stem Cell-Based Gene Therapy for Immune Deficiencies: A Journey from Mouse Cage to Bed Side door Laura Garcia-Perez, Anita Ordas, Kirsten Canté-Barrett, Pauline Meij, Karin Pike-Overzet, Arjan Lankester, Frank J. T. Staal

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Preclinical development of BCG.HIVA2auxo.int, harboring an integrative expression vector, for a HIV-TB Pediatric vaccine.... door Aakash Mahant, Narcís Saubi, Yoshiki Eto, Núria Guitart, Josep Ma Gatell, Tomáš Hanke, Joan Joseph

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Radiopharmaceuticals for PET Imaging - Issue A

Onderwerpen: “…preclinical development…”
DOAB: download the publication
DOAB: description of the publication

Functional humanization of immunoglobulin heavy constant gamma 1 Fc domain human FCGRT transgenic mice door Benjamin E. Low, Gregory J. Christianson, Emily Lowell, Wenning Qin, Michael V. Wiles

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Metal‐HisTag coordination for remote loading of very small quantities of biomacromolecules into PLGA microspheres door Jason Albert, Rae Sung Chang, George A. Garcia, Steven P. Schwendeman

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