Search Results - "allosteric"

Structural and functional characterization of C0021158, a high-affinity monoclonal antibody that inhibits Arginase 2 function via a novel non-competitive mechanism of action by Mark Austin, Daniel Burschowsky, Denice T.Y. Chan, Lesley Jenkinson, Stuart Haynes, Agata Diamandakis, Chitra Seewooruthun, Alexandra Addyman, Sebastian Fiedler, Stephanie Ryman, Jessica Whitehouse, Louise H. Slater, Andreas V. Hadjinicolaou, Uzi Gileadi, Ellen Gowans, Yoko Shibata, Michelle Barnard, Teresa Kaserer, Pooja Sharma, Nadia M. Luheshi, Robert W. Wilkinson, Tristan J. Vaughan, Sarah V. Holt, Vincenzo Cerundolo, Mark D. Carr, Maria A. T. Groves

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Gating Properties of Mutant Sodium Channels and Responses to Sodium Current Inhibitors Predict Mexiletine-Sensitive Mutations of Long QT Syndrome 3 by Gang Li, Ryan L. Woltz, Cheng-yu Wang, Lu Ren, Pei-xin He, Shan-dong Yu, Xue-qin Liu, Vladimir Yarov-Yarovoy, Dan Hu, Nipavan Chiamvimonvat, Nipavan Chiamvimonvat, Lin Wu, Lin Wu

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Direct small molecule ADaM-site AMPK activators reveal an AMPKγ3-independent mechanism for blood glucose lowering by Nicolas O. Jørgensen, Rasmus Kjøbsted, Magnus R. Larsen, Jesper B. Birk, Nicoline R. Andersen, Bina Albuquerque, Peter Schjerling, Russell Miller, David Carling, Christian K. Pehmøller, Jørgen F.P. Wojtaszewski

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Essential Control of the Function of the Striatopallidal Neuron by Pre-coupled Complexes of Adenosine A2A-Dopamine D2 Receptor Heterotetramers and Adenylyl Cyclase by Sergi Ferré, Jordi Bonaventura, Wendy Zhu, Candice Hatcher-Solis, Jaume Taura, Jaume Taura, César Quiroz, Ning-Sheng Cai, Estefanía Moreno, Verónica Casadó-Anguera, Alexxai V. Kravitz, Kimberly R. Thompson, Dardo G. Tomasi, Gemma Navarro, Arnau Cordomí, Leonardo Pardo, Carme Lluís, Carmen W. Dessauer, Nora D. Volkow, Vicent Casadó, Francisco Ciruela, Francisco Ciruela, Diomedes E. Logothetis, Daniel Zwilling

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BDK inhibition acts as a catabolic switch to mimic fasting and improve metabolism in mice by Eliza Bollinger, Matthew Peloquin, Jenna Libera, Bina Albuquerque, Evanthia Pashos, Arun Shipstone, Angela Hadjipanayis, Zhongyuan Sun, Gang Xing, Michelle Clasquin, John C. Stansfield, Brendan Tierney, Steven Gernhardt, C. Parker Siddall, Timothy Greizer, Frank J. Geoly, Sarah R. Vargas, Lily C. Gao, George Williams, Mackenzie Marshall, Amy Rosado, Claire Steppan, Kevin J. Filipski, Bei B. Zhang, Russell A. Miller, Rachel J. Roth Flach

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Coevolution of the Ile1,016 and Cys1,534 Mutations in the Voltage Gated Sodium Channel Gene of Aedes aegypti in Mexico. by Farah Z Vera-Maloof, Karla Saavedra-Rodriguez, Armando E Elizondo-Quiroga, Saul Lozano-Fuentes, William C Black Iv

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Compound- and fiber type-selective requirement of AMPKγ3 for insulin-independent glucose uptake in skeletal muscle by Philipp Rhein, Eric M. Desjardins, Ping Rong, Danial Ahwazi, Nicolas Bonhoure, Jens Stolte, Matthieu D. Santos, Ashley J. Ovens, Amy M. Ehrlich, José L. Sanchez Garcia, Qian Ouyang, Julian M. Yabut, Mads Kjolby, Mathieu Membrez, Niels Jessen, Jonathan S. Oakhill, Jonas T. Treebak, Pascal Maire, John W. Scott, Matthew J. Sanders, Patrick Descombes, Shuai Chen, Gregory R. Steinberg, Kei Sakamoto

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Expanding the Concept of G Protein-Coupled Receptor (GPCR) Dimer Asymmetry towards GPCR-Interacting Proteins by Ralf Jockers, Pascal Maurice, Maud Kamal

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Structure-Function and Therapeutic Potential of Spider Venom-Derived Cysteine Knot Peptides Targeting Sodium Channels by Fernanda C. Cardoso, Richard J. Lewis

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A Novel PARP Inhibitor YHP-836 For the Treatment of BRCA-Deficiency Cancers by Tingting Du, Zhihui Zhang, Jie Zhou, Li Sheng, Haiping Yao, Ming Ji, Bailing Xu, Xiaoguang Chen, Xiaoguang Chen

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A Model of Glucocorticoid Receptor Interaction With Coregulators Predicts Transcriptional Regulation of Target Genes by Federico Monczor, Antonia Chatzopoulou, Carlos Daniel Zappia, René Houtman, Onno C. Meijer, Carlos P. Fitzsimons

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CONTRIBUTIONS OF INTRACELLULAR IONS TO Kv CHANNEL VOLTAGE SENSOR DYNAMICS. by Samuel eGoodchild, David eFedida

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Activation of Glutathione Peroxidase 4 as a Novel Anti-inflammatory Strategy by Cong Li, Xiaobing Deng, Xiaowen Xie, Ying Liu, Ying Liu, José Pedro Friedmann Angeli, Luhua Lai, Luhua Lai, Luhua Lai

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Mechanisms for redox-regulation of protein kinase C by Susan F. Steinberg

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Clinical Application and Research Progress of Remimazolam for Pediatric Patients by Bai C, Xu M, Guo Y, Jin Y, Zhao X

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Flavonoids as GABAA receptor ligands: the whole story? by Wasowski C, Marder M

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Small-Molecule Modulators of Sigma1 and Sigma2/TMEM97 in the Context of Cancer: Foundational Concepts and Emerging Themes by Halley M. Oyer, Christina M. Sanders, Felix J. Kim

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Effects of Selective Estrogen Receptor Modulators on Plasma Membrane Estrogen Receptors and Catecholamine Synthesis and Secretion in Cultured Bovine Adrenal Medullary Cells by Hirohide Inagaki, Yumiko Toyohira, Keita Takahashi, Susumu Ueno, Go Obara, Toshinori Kawagoe, Masato Tsutsui, Toru Hachisuga, Nobuyuki Yanagihara

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6-Phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 and 4: A pair of valves for fine-tuning of glucose metabolism in human cancer by Mei Yi, Yuanyuan Ban, Yixin Tan, Wei Xiong, Guiyuan Li, Bo Xiang

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Low-Impact Ampakine CX1739 Exerts Pro-Cognitive Effects and Reverses Opiate-Induced Respiratory Depression in Rodents by Daniel Pierce Radin, Sheng Zhong, Rok Cerne, Mohammed Shoaib, Jeffrey M. Witkin, Arnold Lippa

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