Search Results - "allosteric"

Pharmacodynamic Response to Deucravacitinib, an Oral, Selective, Allosteric TYK2 Inhibitor, in a Global, Phase 2, Randomized, Double-Blind, Placebo-Controlled Psoriasis Trial by Ian M. Catlett, Lu Gao, Yanhua Hu, Subhashis Banerjee, James G. Krueger

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Molecular docking and biochemical validation of (-)-syringaresinol-4-O-β-D-apiofuranosyl-(1→2)-β-D-glucopyranoside binding to an allosteric site in monoamine transporters by Hanhe Liu, Yingyao Wu, Chan Li, Qingfa Tang, Qingfa Tang, Yuan-Wei Zhang

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Structural Bioinformatics and Protein Docking Analysis of the Molecular Chaperone-Kinase Interactions: Towards Allosteric Inhibition of Protein Kinases by Targeting the Hsp90-Cdc37 Chaperone Machinery by Gennady Verkhivker, Elizabeth Berrigan, Nathan Lawless, Kristin Blacklock

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Scaffold hopping and optimisation of 3',4'-dihydroxyphenyl- containing thienopyrimidinones: synthesis of quinazolinone derivatives as novel allosteric inhibitors of HIV-1 reverse transcriptase-associated ribonuclease H by Graziella Tocco, Francesca Esposito, Pierluigi Caboni, Antonio Laus, John A. Beutler, Jennifer A. Wilson, Angela Corona, Stuart F. J. Le Grice, Enzo Tramontano

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Sigma Receptors

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Correlation of Receptor Occupancy of Metabotropic Glutamate Receptor Subtype 1 (mGluR1) in Mouse Brain With In vivo Activity of Allosteric mGluR1 Antagonists by Gentaroh Suzuki, Hiroko Kawagoe-Takaki, Takao Inoue, Toshifumi Kimura, Hirohiko Hikichi, Takashi Murai, Akio Satow, Mikiko Hata, Shunsuke Maehara, Satoru Ito, Hiroshi Kawamoto, Satoshi Ozaki, Hisashi Ohta

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Analysis of M4 Transmembrane Segments in NMDA Receptor Function: A Negative Allosteric Modulatory Site at the GluN1 M4 is Determining the Efficiency of Neurosteroid Modulation by Kai Langer, Adriana Müller-Längle, Jannik Wempe, Bodo Laube, Bodo Laube

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T‐495, a novel low cooperative M1 receptor positive allosteric modulator, improves memory deficits associated with cholinergic dysfunction and is characterized by low gastrointestinal side effect risk by Takao Mandai, Yuu Sako, Emi Kurimoto, Yuji Shimizu, Minoru Nakamura, Makoto Fushimi, Ryouta Maeda, Maki Miyamoto, Haruhide Kimura

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Cenobamate, a Sodium Channel Inhibitor and Positive Allosteric Modulator of GABA_A Ion Channels, for Partial Onset Seizures in Adults: A Comprehensive Review and Clinical Implications by Dustin R. Latimer, Amber N. Edinoff, Rachel D. Ruff, Kelsey C. Rooney, Kayla M. Penny, Shaan B. Patel, Suresh Sabbenahalli, Adam M. Kaye, Elyse M. Cornett, Omar Viswanath, Ivan Urits, Alan D. Kaye

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Dalzanemdor (SAGE‐718), a novel, investigational N‐methyl‐D‐aspartate receptor positive allosteric modulator: Safety, tolerability, and clinical pharmacology in randomized dose‐finding studies in healthy participants and an open‐label study in participants with Huntington's disease by Aaron Koenig, Michael Lewis, Jeff Wald, Sigui Li, Mustafa Varoglu, Jing Dai, Abdul Sankoh, Katrina Paumier, James Doherty, Mike Quirk

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Discovery of the SHP2 allosteric inhibitor 2-((3R,4R)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)-5-(2,3-dichlorophenyl)-3-methylpyrrolo[2,1-f][1,2,4] triazin-4(3H)-one by Yanmei Luo, Jin Li, Yuliang Zong, Mengxin Sun, Wan Zheng, Jiapeng Zhu, Liu Liu, Bing Liu

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Role of DNA Methyltransferases in the Epigenome by Jeltsch, Albert

Subjects: “…allosteric regulation…”
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Advances in Cross-Coupling Reactions

Subjects: “…allosteric modulators…”
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Computational Approaches in Discovery & Design of Antimicrobial Peptides

Subjects: “…allosteric inhibition…”
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Potential Health Benefits of Fruits and Vegetables II

Subjects: “…allosteric binding site…”
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In Silico Strategies for Prospective Drug Repositionings

Subjects: “…allosteric inhibitors…”
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In Silico Strategies for Prospective Drug Repositionings

Subjects: “…allosteric inhibitors…”
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Opioids and Their Receptors Present and Emerging Concepts in Opioid Drug Discovery II

Subjects: “…allosteric modulation…”
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Targets, Tracers and Translation - Novel Radiopharmaceuticals Boost Nuclear Medicine by Reischl, Gerald

Subjects: “…allosteric modulator…”
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Molecular Modeling in Drug Design by Wade, Rebecca

Subjects: “…allosterism…”
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